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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 715 - 721 (7page)
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초록· 키워드
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Background: Hydroquinone (HQ) is frequently combined with retinoic acid (RA) to enhance lightening efficacy, which may also affect skin irritancy. Although skin irritation leads to postinflammatory hyperpigmentation, little research has been performed to compare skin irritancy between each component and the combination. Objective: This study was done to examine whether HQ-RA combination increased skin irritation induced by HQ or RA alone. Methods: Patch testing was performed using maximum therapeutic and higher concentrations of HQ and RA in 10 volunteers, and then, it was performed using their popular therapeutic concentrations and combination in the other 20 volunteers. In vitro irritation was also assessed in primary cultured normal human keratinocytes treated with 80% and 50% cell survival doses of HQ, 80% cell survival dose of RA, and their combination. Results: The combination in patch testing induced stronger erythema than the corresponding concentrations of HQ and RA, which was remarkable with use of combination of higher concentrations. In cultured keratinocytes, the RA combination significantly decreased cell viability, but increased cytotoxicity and extracellular interleukin 1 alpha release with corresponding doses of HQ.
Conclusion: The results of patch tests and in vitro irritation assessment tests suggested that HQ and RA increased skin irritation when used in combination.
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등록된 정보가 없습니다.
참고문헌 (21)
참고문헌 신청
Akhavan A / 2003 / Topical acne drugs: review of clinical properties, systemic exposure, and safety / Am J Clin Dermatol 4 : 473 ~ 492
Ale IS / 2014 / Irritant contact dermatitis / Rev Environ Health 29 : 195 ~ 206
Basketter D / 1997 / Visual assessment of human skin irritation: a sensitive and reproducible tool / Contact Dermatitis 37 : 218 ~ 220
Corsini E / 1998 / Cytokines and irritant contact dermatitis / Toxicol Lett : 102 ~
De Groot AC / 2006 / Contact dermatitis / Springer-Verlag Berlin Heidelberg : 907 ~ 928
Ale IS / 2014 / Irritant contact dermatitis / Rev Environ Health 29 : 195 ~ 206
Basketter D / 1997 / Visual assessment of human skin irritation: a sensitive and reproducible tool / Contact Dermatitis 37 : 218 ~ 220
Corsini E / 1998 / Cytokines and irritant contact dermatitis / Toxicol Lett : 102 ~
De Groot AC / 2006 / Contact dermatitis / Springer-Verlag Berlin Heidelberg : 907 ~ 928
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