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논문 기본 정보

자료유형
학술저널
저자정보
Jun Seunghee (Department of Preventive Medicine, College of Medicine, Ewha Womans University, Seoul, Korea.Graduate Program in System Health Science and Engineering, Department of Preventive Medicine, Col) Park Hyunjin (Department of Preventive Medicine, College of Medicine, Ewha Womans University, Seoul, Korea.Graduate Program in System Health Science and Engineering, Department of Preventive Medicine, Col) Kim Ui-Jeong (Department of Preventive Medicine, College of Medicine, Ewha Womans University, Seoul, Korea.) Lee Hye Ah (Clinical Trial Center, Ewha Womans University Mokdong Hospital, Seoul, Korea.) Park Bomi (Department of Preventive Medicine, College of Medicine, Chung-Ang University, Seoul, Korea.) Lee Soon Young (Department of Preventive Medicine and Public Health, Ajou University School of Medicine, Suwon, Korea.) Jee Sun Ha (Institute for Health Promotion, Department of Epidemiology and Health Promotion, Graduate School of Public Health, Yonsei University, Seoul, Korea.) Park Hyesook (Department of Preventive Medicine, College of Medicine, Ewha Womans University, Seoul, Korea.Graduate Program in System Health Science and Engineering, Department of Preventive Medicine, Col)
저널정보
대한의학회 Journal of Korean Medical Science Journal of Korean Medical Science Vol.39 No.22
발행연도
2024.6
수록면
1 - 15 (15page)
DOI
10.3346/jkms.2024.39.e185

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Background: Alcohol consumption is a major risk factor for cancer, and when combined with smoking, the risk increases. Nevertheless, few studies have comprehensively evaluated the combined effects of alcohol consumption and smoking on the risk of various cancer types. Therefore, to assess these effects, we conducted a systematic review and meta-analysis. Methods: We performed a systematic search of five literature databases, focusing on cohort and case-control studies. Considering exposure levels, we quantified the combined effects of alcohol consumption and smoking on cancer risk and assessed multiplicative interaction effects. Results: Of 4,452 studies identified, 24 (4 cohort studies and 20 case-control studies) were included in the meta-analysis. We detected interaction effect of light alcohol and moderate smoking on head and neck cancer risk (relative risk [RR], 4.26; 95% confidence interval [CI], 2.50–7.26; I 2 = 65%). A synergistic interaction was observed in heavy alcohol and heavy smoking group (RR, 35.24; 95% CI, 23.17–53.58; I 2 = 69%). In more detailed cancer types, the interaction effect of heavy alcohol and heavy smoking was noticeable on oral (RR, 36.42; 95% CI, 24.62–53.87; I 2 = 46%) and laryngeal (RR, 38.75; 95% CI, 19.25–78.01; I 2 = 69%) cancer risk. Conclusion: Our study provided a comprehensive summary of the combined effects of alcohol consumption and smoking on cancers. As their consumption increased, the synergy effect became more pronounced, and the synergy effect was evident especially for head and neck cancer. These findings provide additional evidence for the combined effect of alcohol and smoking in alcohol guidelines for cancer prevention.

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