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논문 기본 정보

자료유형
학술저널
저자정보
Cheol Min Shin (Department of Internal Medicine, Seoul National University Bundang Hospital) Kyungdo Han (Department of Statistics and Actuarial Science, Soongsil University) 강승주 (서울대학교병원 강남센터 소화기내과) Jin Hyung Jung (Department of Medical Statistics, College of Medicine, The Catholic University of Korea) Eun Hyo Jin (Healthcare System Gangnam Center, Seoul National University Hospital) Joo Hyun Lim (Department of Internal Medicine, Healthcare System Gangnam Center, Seoul National University Hospital) Yoon Jin Choi (Division of Gastroenterology, Department of Internal Medicine, Yonsei University College of Medicine) 윤혁 (분당서울대학교병원) Young Soo Park (Department of Internal Medicine, Seoul National University Bundang Hospital) Nayoung Kim (Department of Internal Medicine, Seoul National University Bundang Hospital) Dong Ho Lee (Department of Internal Medicine, Seoul National University Bundang Hospital)
저널정보
대한위암학회 Journal of Gastric Cancer Journal of Gastric Cancer Vol.24 No.2
발행연도
2024.4
수록면
145 - 158 (14page)
DOI
https://doi.org/10.5230/jgc.2024.24.e2

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Purpose: Although smoking and alcohol consumption are known risk factors for gastric cancer (GC), studies assessing their effects on early-onset GC are limited. In this nationwide, population-based, prospective cohort study, we assessed the effects of smoking and alcohol consumption on early-onset GC in patients aged <50 years. Materials and Methods: We analyzed data of patients aged 20–39 years who underwent cancer and general health screening in the Korean National Health Screening Program between 2009 and 2012. We calculated the adjusted hazard ratios (aHR) and 95% confidence intervals (CI) for GC incidence until December 2020. Results: We enrolled 6,793,699 individuals (men:women=4,077,292:2,716,407) in this cohort. The mean duration of follow-up was 9.4 years. During follow-up, 9,893 cases of GC (men:women=6,304:3,589) were reported. Compared with the aHRs (95% CI) of never-smokers, those of former and current-smokers were 1.121 (1.044–1.205) and 1.282 (1.212–1.355), respectively. Compared with the aHRs (95% CI) of non-consumers, those of low-moderate- and high-risk alcohol consumers were 1.095 (1.046–1.146) and 1.212 (1.113–1.321), respectively. GC risk was the highest in current-smokers and high-risk alcohol consumers (1.447 [1.297–1.615]). Interestingly, alcohol consumption and smoking additively increased the GC risk in men but not in women (Pinteraction=0.002). Conclusion: Smoking and alcohol consumption are significant risk factors for early-onset GC in young Koreans. Further studies are needed to investigate sex-based impact of alcohol consumption and smoking on GC incidence in young individuals.

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