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논문 기본 정보

자료유형
학술저널
저자정보
Kang Min Seok (Department of Internal Medicine, Yonsei University Wonju College of Medicine, Wonju, Korea) Kim Dong Young (Department of Internal Medicine, Yonsei University Wonju College of Medicine, Wonju, Korea) Kim Sung Hwa (Department of Biostatistics, Yonsei University Wonju College of Medicine, Wonju, Korea) Kim Jae Seok (Department of Internal Medicine, Yonsei University Wonju College of Medicine, Wonju, Korea) Yang Jae Won (Department of Internal Medicine, Yonsei University Wonju College of Medicine, Wonju, Korea) Han Byoung Geun (Department of Internal Medicine, Yonsei University Wonju College of Medicine, Wonju, Korea) Kang Dae Ryong (Department of Precision Medicine, Yonsei University Wonju College of Medicine, Wonju, Korea) Lee Jinhee (Department of Psychiatry, Yonsei University Wonju College of Medicine, Wonju, Korea) Lee Jun Young (Department of Internal Medicine, Yonsei University Wonju College of Medicine, Wonju, KoreaTransplantation Center, Wonju Severance Christian Hospital, Wonju, Korea)
저널정보
대한이식학회 Clinical Transplantation and Research Clinical Transplantation and Research 제38권 제2호
발행연도
2024.6
수록면
98 - 105 (8page)
DOI
10.4285/ctr.24.0004

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Background: Kidney transplantation (KT) improves physical and psychological prognoses for patients with end-stage kidney disease (ESKD). However, few comparative studies have examined depression and suicide rates among patients with ESKD treated with dialysis versus KT. Methods: Data on 21,809 patients with ESKD were extracted from the Korean National Health Insurance Service database, extending from January 2002 to December 2018. These patients exhibited no history of depression or insomnia before starting renal replacement therapy. Outcomes were compared between dialysis and KT recipients using 1:2 propensity score matching (PSM). Results: Of the patients, 17,649 received dialysis (hemodialysis, 15,537; peritoneal dialysis, 2,112), while 4,160 underwent KT. Of those on dialysis, 45.04% (7,949) experienced insomnia, compared to 25.72% (1,070) of KT recipients (P<0.001). Depression was more frequent among dialysis recipients (22.77%, 4,019) than KT recipients (8.61%, 358; P<0.001). Additionally, those on dialysis had a higher incidence of suicide (0.19%, 33) than recipients of KT (0.12%, 5; P=0.047). After PSM, the hazard ratio (HR) for depression in patients on dialysis compared to KT recipients was 1.76 (95% confidence interval [CI], 1.56–1.99). In subgroup analysis, the relative likelihood of depression among dialysis recipients was particularly high for residents of urban areas (HR, 2.10; 95% CI, 1.80–2.44) and patients under 65 years old (HR, 1.82; 95% CI, 1.62–2.09). Conclusions: KT recipients exhibit a lower suicide rate than patients on dialysis. Furthermore, KT is associated with a lower prevalence of depression among Korean patients with ESKD, particularly urban residents and individuals under 65 years old.

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