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논문 기본 정보

자료유형
학술저널
저자정보
구본산 (인제대학교) Jang Miso (Department of Biomedical Engineering, Asan Medical Institute of Convergence Science and Technology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, KoreaDepartment of Me) Oh Ji Seon (Department of Information Medicine, Big Data Research Center, Asan Medical Center, Seoul, Korea.) Shin Keewon (Department of Biomedical Engineering, Asan Medical Institute of Convergence Science and Technology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea) Lee Seunghun (Department of Radiology, Hanyang University Hospital for Rheumatic Diseases, Seoul, Korea) Joo Kyung Bin (Department of Radiology, Hanyang University Hospital for Rheumatic Diseases, Seoul, Korea) Kim Namkug (Department of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, KoreaDepartment of Convergence Medicine, Asan Medical Center, University of Ulsan College of Med) 김태환 (한양대학교)
저널정보
대한류마티스학회 대한류마티스학회지 Journal of Rheumatic Diseases Vol.31 No.2
발행연도
2024.4
수록면
97 - 107 (11page)
DOI
10.4078/jrd.2023.0056

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Objective: Ankylosing spondylitis (AS) is chronic inflammatory arthritis causing structural damage and radiographic progression to the spine due to repeated and continuous inflammation over a long period. This study establishes the application of machine learning models to predict radiographic progression in AS patients using time-series data from electronic medical records (EMRs). Methods: EMR data, including baseline characteristics, laboratory findings, drug administration, and modified Stoke AS Spine Score (mSASSS), were collected from 1,123 AS patients between January 2001 and December 2018 at a single center at the time of first (T1), second (T2), and third (T3) visits. The radiographic progression of the (n+1)th visit (Pn+1=(mSASSSn+1–mSASSSn)/(Tn+1–Tn)≥1 unit per year) was predicted using follow-up visit datasets from T1 to Tn. We used three machine learning methods (logistic regression with the least absolute shrinkage and selection operation, random forest, and extreme gradient boosting algorithms) with three-fold cross-validation. Results: The random forest model using the T1 EMR dataset best predicted the radiographic progression P2 among the machine learning models tested with a mean accuracy and area under the curves of 73.73% and 0.79, respectively. Among the T1 variables, the most important variables for predicting radiographic progression were in the order of total mSASSS, age, and alkaline phosphatase. Conclusion: Prognosis predictive models using time-series data showed reasonable performance with clinical features of the first visit dataset when predicting radiographic progression.

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