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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 248 - 256 (9page)
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Objective. Acute anterior uveitis (AAU) is the most common extra-articular manifestation in patients with axial spondyloarthritis (axSpA). However, the relationship between AAU and radiographic progression in axSpA remains unclear. Hence, we investigated whether the presence of AAU is associated with radiographic structural damage in patients with axSpA. Methods. Clinical and radiographic data were obtained from 253 patients with axSpA. Radiographic progression over 2 years was assessed using the modified Stoke Ankylosing Spondylitis Spine Score (mSASSS). Progression was defined as mSASSS worsening by ≥two units. Using propensity score (PS) matching, differences between patients with and without AAU were analyzed. Results. The proportion of progressors among patients with AAU was lower than that of patients without AAU (13.6% vs. 29.5%, p=0.058). The rate of increase in mSASSS and number of syndesmophytes were lower in patients with AAU than patients without AAU (0.57±1.37 vs. 1.02±1.79, p=0.085 and 0.46±1.45 vs. 0.83±1.62, p=0.158). In multivariate regression analysis, presence of AAU was independently associated with slowed radiographic progression (odds ratio [95% confidence interval] 0.21 [0.07, 0.67], p=0.004). Conclusion. PS-matched axSpA patients with AAU showed significantly less radiographic progression than those without AAU.
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참고문헌 (40)
참고문헌 신청
Sieper J / 2015 / Axial spondyloarthritis / Nat Rev Dis Primers 1:15013
Sieper J / 2017 / Axial spondyloarthritis / Lancet 390:73~84
Boonen A / 2006 / The burden of ankylosing spondylitis / J Rheumatol Suppl 78:4~11
Krüger K / 2018 / Ankylosing spondylitis causes high burden to patients and the healthcare system: results from a German claims database analysis / Rheumatol Int 38:2121~2131
Stolwijk C / 2015 / The epidemiology of extra-articular manifestations in ankylosing spondylitis: a populationbased matched cohort study / Ann Rheum Dis 74:1373~1378
Sieper J / 2017 / Axial spondyloarthritis / Lancet 390:73~84
Boonen A / 2006 / The burden of ankylosing spondylitis / J Rheumatol Suppl 78:4~11
Krüger K / 2018 / Ankylosing spondylitis causes high burden to patients and the healthcare system: results from a German claims database analysis / Rheumatol Int 38:2121~2131
Stolwijk C / 2015 / The epidemiology of extra-articular manifestations in ankylosing spondylitis: a populationbased matched cohort study / Ann Rheum Dis 74:1373~1378
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