Purpose: This study aimed to examine the effects of nurses' self-leadership, work environments, and information competence on their work performance. Methods: A survey was conducted between March 5 and 18, 2024 with 200 nurses from general hospitals in Deajeon City. The data were analyzed using descriptive statistics, correlation analysis, and multiple regressions. Results: Nursing work performance showed significant correlations with self-leadership (r=.61, p<.001), nursing work environment (r=.38, p<.001), and nursing information competence (r=.69, p<.001). Factors influencing work performance were self-leadership (β=.16, p=.006), nursing information competence (β=.58, p<.001), age (<30) (β=.12, p<.024), working pattern (permanent) (β=.11, p=.029), and working in desired department (β=.18, p<.001), explaining 65.4% of the variance. Conclusion: Based on these findings, systematic support that enhances self-leadership and the development and implementation of educational programs related to medical information are necessary to improve nursing information competence.