지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2024.12
- 수록면
- 255 - 263 (9page)
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초록· 키워드
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Objectives: Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis (MTB) bacteria. According to a World Health Organization report, a third of the world’s population has latent TB infection (LTBI), and 5%–10% of people with LTBI are at risk of developing active TB (ATB) in their lifetime. Therefore, it is important to quickly and accurately distinguish between ATB and LTBI.
Methods: In the present study, serum C-reactive protein (CRP) levels from a total of 110 serum samples from 28 ATB patients, 29 LTBI, and 53 healthy individual groups were analyzed using a quantitative suspension bead array. The results were compared with those of acid-fast bacilli staining, mycobacterial cultures, MTB-polymerase chain reaction (PCR), chest X-ray (CXR), complete blood count, white blood cell (WBC) differential count, and erythrocyte sedimentation rate (ESR) examination.
Results: The results showed that serum CRP levels in the ATB group were significantly higher than in the LTBI and healthy individual groups. Serum CRP levels in patients positive for mycobacterial culture, MTB-PCR, and CXR examinations were higher than in individuals who were negative for these examinations. In addition, total WBC, neutrophil, and lymphocyte counts, and ESR showed positive correlations with serum CRP levels.
Conclusion: We evaluated the feasibility of serum CRP levels as a potential marker for TB diagnosis using blood samples, and these results could provide baseline data for comparing the expression patterns of the marker in whole blood of ATB, LTBI, and healthy groups of individuals.
Methods: In the present study, serum C-reactive protein (CRP) levels from a total of 110 serum samples from 28 ATB patients, 29 LTBI, and 53 healthy individual groups were analyzed using a quantitative suspension bead array. The results were compared with those of acid-fast bacilli staining, mycobacterial cultures, MTB-polymerase chain reaction (PCR), chest X-ray (CXR), complete blood count, white blood cell (WBC) differential count, and erythrocyte sedimentation rate (ESR) examination.
Results: The results showed that serum CRP levels in the ATB group were significantly higher than in the LTBI and healthy individual groups. Serum CRP levels in patients positive for mycobacterial culture, MTB-PCR, and CXR examinations were higher than in individuals who were negative for these examinations. In addition, total WBC, neutrophil, and lymphocyte counts, and ESR showed positive correlations with serum CRP levels.
Conclusion: We evaluated the feasibility of serum CRP levels as a potential marker for TB diagnosis using blood samples, and these results could provide baseline data for comparing the expression patterns of the marker in whole blood of ATB, LTBI, and healthy groups of individuals.
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ABSTRACT
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
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