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논문 기본 정보

자료유형
학술저널
저자정보
Akinpelu Moronkeji (University of Medical Science) Ayodeji Olayanju (Kingston University London) Temidayo Daniel Adeniyi (University of Ilorin) Adedeji David Atere (Osun State University) Adebimpe Iyanuoluwa Moronkeji (Elizade University Ilara Mokin) Michael Chuks Igunbor (Achievers University Owo) Abiodun Oyeleke (Federal University Oye-Ekiti) Frederick Olusegun Akinbo (University of Benin)
저널정보
환경독성보건학회 Environmental Analysis Health and Toxicology Environmental Analysis Health and Toxicology Vol.39 No.4
발행연도
2024.12
수록면
54 - 63 (10page)

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Petroleum-powered generators are commonly used in many developing countries as an alternative to meet utility demands. Generator exhaust emission significantly contributes to air pollution, which remains a constant threat to human health due to the presence of aromatic hydrocarbons and other harmful gases. This study assessed oxidative stress parameters in response to exhaust emission from gasoline generator engine in adult male wistar rats. Forty-eight (48) adult wistar rats weighing between 180-200g were randomly allocated to four (4) groups (A-D) of twelve (12) rats each. After the acclimatization period, the control group (A) were kept unexposed, whereas rats in groups (C-D) were exposed daily at 2, 4, and 8-hour intervals for 4, 8, and 12 weeks, respectively. Tissue samples were obtained at four weeks intervals. Fresh lung tissues weighing 1g were rinsed twice in phosphate-buffered saline (PBS, pH 8.0), homogenized and centrifuged at 3000 revolutions per minute for 20 min at 4°C. Supernatant levels of malondialdehyde (MDA), superoxide dismutase (SOD), glutathione peroxidase (GPx), glutathione S-transferase (GST), reduced glutathione (GSH), nitric oxide (NO), hydrogen peroxide (H2O2), catalase (CAT), and total antioxidant status (TAS) were determined using standard protocols. The findings revealed elevated oxidant levels of MDA, NO, and H2O2, whereas SOD, GPX, GST, GSH, CAT, and TAS were significantly reduced across the exposure time points compared to the unexposed control rats (p < 0.05). The research findings revealed that exposure to emissions from gasoline generators induced oxidative stress in the exposed rats, with the extent of disruption to their oxidative balance dependent on the duration and length of exposure time.
#Air pollution #health #oxidative stress #Nigeria #electricity #Rats

목차

Abstract
Introduction
Materials and Methods
Results
Discussion
Conclusions
References

참고문헌 (41)

참고문헌 신청
World Health Organization (WHO). WHO global air quality guidelines: particulate matter (PM2.5 and PM10), ozone, nitrogen dioxide, sulfur dioxide and carbon monoxide. WHO; 2021. [cited June 24, 2024]. Available from: https://www.who.int/publications/i/item/9789240034228 google schola World Health Organization (WHO). Ambient (outdoor) air pollution. [cited June 24, 2024]. Available from: https://www.who.int/news-room/fact-sheets/detail/ambient-(outdoor)-air-quality-and-health?gad_source=1&gclid=Cj0KCQjwvb-zBhCmARIsAAfUI2uht3D3H9sSC_f4cCZwKJkYFA1xGuiMGJc8xCmOuHgYhXC3yi7HDpgaAgJQEALw_wcB google schola World Health Organization (WHO). Air pollution and child health: prescribing clean air. [cited June 24, 2024]. Available from: https://www.who.int/publications/i/item/air-pollution-and-child-health google schola Oladimeji T, Sonibare J, Odunfa M, Ayeni A. Modeling of criteria air pollutant emissions from selected Nigeria petroleum refineries. Journal of Power and Energy Engineering 2015;3(6):31-45. https://doi.org/10.4236/jpee.2015.36004 google schola Croitoru L, Akpokodje J, Chang JC, Kelly A. The Cost of Air Pollution in Lagos. [cited June 24, 2024]. Available from: https://www.worldbank.org/en/topic/environment/publication/the-cost-of-air-pollution-in-lagos google schola

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