Omega-3 fatty acids inhibit oxidative stress in a rat model of liver regeneration

Ozgur Firat; Ozer Makay; Levent Yeniay; Goksel Gokce; Cigdem Yenisey; Ahmet Coker

추천

검색

질문

자료유형: 학술저널

저자정보: Ozgur Firat (Ege University Hospital) Ozer Makay (Ege University Hospital) Levent Yeniay (Ege University Hospital) Goksel Gokce (Ege University) Cigdem Yenisey (Adnan Menderes University Hospital) Ahmet Coker (Ege University Hospital)

저널정보: 대한외과학회 Annals of Surgical Treatment and Research Annals of Surgical Treatment and Research Vol.93 No.1

발행연도: 2017.7

수록면: 1 - 10 (10page)

이용수

📌

연구주제

📖

연구배경

🔬

연구방법

🏆

연구결과

초록· 키워드

오류제보하기

Purpose: Lipid peroxidation and consequent reactive oxygen species in the setting of oxidative stress have crucial roles in liver regeneration, which may adversely affect the regeneration itself and lead to liver failure. The aim of the current study is to investigate whether omega-3 fatty acid supplementation inhibits oxidative stress in an experimental model of liver regeneration.
Methods: Forty rats were allocated to four groups. Rats in group A received a sham operation. Rats in group B were subjected to right portal vein ligation (RPVL) and saline infusion. Rats in groups C and D were subjected to RPVL and total parenteral nutrition (TPN) with an all-in-one admixture containing a soybean oil based lipid emulsion. Rats in group D were additionally supplemented with omega-3 fatty acid infusion. Oxidative stresses in the blood and liver were measured by glutathione, superoxide dismutase, catalase, glutathione peroxidase, malondialdehyde, and nitric oxide.
Results: Omega-3 supplementation to the TPN solution significantly corrected alterations in the blood and tissue concentrations of oxidants and anti-oxidants during regeneration (P ＜ 0.05).
Conclusion: Omega-3 fatty acid supplementation to the TPN solution revealed promising results in removal of oxidative stress that emerges during liver regeneration.

#Omega-3 fatty acids #Oxidative stress #Liver regeneration

참고문헌 (30)

참고문헌 신청

[학술지(정기간행물)] - Yang S / 2004 / Mitochondrial respiratory function and antioxidant capacity in normal and cirrhotic livers following partial hepatectomy / Cell Mol Life Sci 61 : 220 ~ 229

[학술지(정기간행물)] - Horimoto M / 2004 / Uncoupling protein-2 deficiency promotes oxidant stress and delays liver regeneration in mice / Hepatology 39 : 386 ~ 392

[학술지(정기간행물)] - Hong JY / 2009 / Oxidant stress-induced liver injury in vivo: role of apoptosis, oncotic necrosis, and c-Jun NH2-terminal kinase activation / Am J Physiol Gastrointest Liver Physiol 296 : G572 ~ G581

[학술지(정기간행물)] - El-Badry AM / 2007 / Omega 3 - Omega 6: What is right for the liver? / J Hepatol 47 : 718 ~ 725

[학술지(정기간행물)] - Kikugawa K / 2003 / Protective effect of supplementation of fish oil with high n-3 polyunsaturated fatty acids against oxidative stress-induced DNA damage of rat liver in vivo / J Agric Food Chem 51 : 6073 ~ 6079

함께 읽어보면 좋을 논문

논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!