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- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2024.1
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- 1 - 12 (12page)
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Recently, the incidence of metabolic dysfunction-associated steatotic liver disease (MASLD) is increasing due to the high prevalence of metabolic conditions, such as obesity and type 2 diabetes mellitus. Steatotic liver is a hotspot for cancermetastasis in MASLD. Altered lipid metabolism, a hallmark of MASLD, remodels the tissue microenvironment, making itconducive to the growth of metastatic liver cancer. Tumors exacerbate the dysregulation of hepatic metabolism by re leasing extracellular vesicles and particles into the liver. Altered lipid metabolism influences the proliferation, differ entiation, and functions of immune cells, contributing to the formation of an immunosuppressive and metastasis-proneliver microenvironment in MASLD. This review discusses the mechanisms by which the steatotic liver promotes livermetastasis progression, focusing on its role in fostering an immunosuppressive microenvironment in MASLD.Furthermore, this review highlights lipid metabolism manipulation strategies for the therapeutic management of metastaticliver cancer.
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