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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2024.9
- 수록면
- 477 - 484 (8page)
- DOI
- 10.1007/s13206-024-00166-y
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초록· 키워드
오류제보하기
Cisplatin, which is commonly used in tumor treatment, and gentamicin, which is widely used as an antibiotic, both induce nephrotoxicity as a side efect. In this study, a nephrotoxicity model for these two drugs was constructed using the organ-on- a-chip technology, which is an alternative to animal tests. Using injection-molded polycarbonate chips, human renal proximal tubular epithelial cells (HRPTECs) and human umbilical vein endothelial cells (HUVECs) were co-cultured to mimic the apical and basolateral sides. To induce nephrotoxicity, cisplatin and gentamicin were administered, and cell viability and toxicity markers were confrmed via cell viability, live/dead staining, and confocal fuorescence microscopy imaging of the samples. In addition, renal tubule function was quantitatively evaluated through transepithelial electrical resistance, glucose reabsorption, and permeability analyses, and the concentrations of the nephrotoxic biomarkers kidney injury molecule-1 and neutrophil gelatinase-associated lipocalin were measured using enzyme-linked immunosorbent assay. An organ-on-a-chip model mimicking the apical and basolateral sides co-cultured with HRPTECs and HUVECs was developed, which served as a nephrotoxicity model with impaired renal function. This model is expected to resolve interspecies discrepancies in nephrotoxicity during drug development and signifcantly reduce the time and cost involved in preclinical and clinical trials.
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