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자료유형
학술저널
저자정보
(고려대학교) (고려대학교) (고려대학교)
저널정보
한국식품과학회 Food Science and Biotechnology Food Science and Biotechnology vol 17. no 6
발행연도
수록면
1,131 - 1,138 (8page)

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초록· 키워드

Diabetic complications are a leading cause of blindness, renal failure, and nerve damage. Additionally, diabetesaccelerated atherosclerosis leads to increased risk of myocardial infarction, stroke, and limb amputation. At the present time, 4 main molecular mechanisms have been implicated in hyperglyceamia-mediated vascular damage. In particular, advanced glycation endproducts (AGE), which are formed by complex, heterogeneous, sugar-derived protein modifications, have been implicated as a major pathogenic process for diabetic complications. Recently, AGE inhibitors such as aminoguanidin, ALT-946, and pyridoxamine have been reported. Such an integrating paradigm provides a new conceptual framework for future research on diabetes complications and on discovering drugs to prevent the progression of AGE-induced maladies.
#advanced glycation endproduct #diabetes mellitus #diabetic complication #inhibitor #reactive oxygen species (ROS)
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  1. Abstract
  2. Introduction
  3. Mechanisms of Diabetic Complications
  4. AGEs and Diabetic Complications
  5. Formation of Various AGEs in vivo and Related Toxicity
  6. AGE Formation During Diabetic Conditions
  7. ROS and Diabetes
  8. Pharmacological Inhibition of AGEs
  9. Conclusion
  10. Acknowledgments
  11. References

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UCI(KEPA) : I410-ECN-0101-2013-573-000858236