지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.9
- 수록면
- 206 - 212 (7page)
이용수
초록· 키워드
오류제보하기
Depression is a type of mood disorder characterized by hypochondriasis, decreased appetite, and insomnia. Depression is a disease that affects more than 100 million people worldwide. 2-Nonadecanone (NAC) is a bioactive substance that constitutes Fomes fomentarius, and NAC is expected to have an antidepressant effect. By using the forced swimming test (FST), we investigated the effects of treatment with NAC on immobility subacutely in rats after oral dosing once a day for 2 days. Serum levels of cytokine interleukin-1 beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha) were determined by enzyme-linked immunosorbent assay (ELISA). Nuclear factor-2 (Nrf-2) and inducible nitric oxide synthases (iNOS) were analyzed by western blot method. NAC dose-dependently decreased immobility in the FST. NAC dosedependently decreased FST-induced increase of cytokine levels, as manifested by significantly stronger effects on IL-1β and TNF-α levels at higher doses than the lowest dose of NAC. Western blot analysis showed that Nrf-2 was significantly lower in the NAC-treated group than in the disease-induced group. The iNOS results were also significantly lower in the NAC-treated group than in the other groups. Considering FST results, the antidepressant effect of NAC is effective. Considering the results of cytokine and protein expression, this anti-depressant effect may be related to the anti-inflammatory effect. Therefore, it can be said that the anti-inflammatory effect of NAC increases the antidepressant effect in the FST experiment.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (18)
참고문헌 신청
[학술지(정기간행물)] - Agarwal P / 2013 / Depression treatment patterns among individuals with osteoarthritis: a cross sectional study / BMC Psychiatry 22 : 111 ~ 121
[학술지(정기간행물)] - Anne GB / 2017 / Upward counterfactual thinking and depression: A meta-analysis / Clinical Psychology 55 : 56 ~ 73
[학술지(정기간행물)] - Bogdanova OV / 2013 / Factors influencing behavior in the forced swim test / Physiol Behav 13 : 227 ~ 239
[학술지(정기간행물)] - Casey DA / 2017 / Depression in Older Adults: A Treatable Medical Condition / Prim Care 44 : 499 ~ 510
[학술지(정기간행물)] - Corn JE / 2014 / Ubiquitin in inflammation: the right linkage makes all the difference / Nat Struct Mol Biol 21 : 297 ~ 300
[학술지(정기간행물)] - Anne GB / 2017 / Upward counterfactual thinking and depression: A meta-analysis / Clinical Psychology 55 : 56 ~ 73
[학술지(정기간행물)] - Bogdanova OV / 2013 / Factors influencing behavior in the forced swim test / Physiol Behav 13 : 227 ~ 239
[학술지(정기간행물)] - Casey DA / 2017 / Depression in Older Adults: A Treatable Medical Condition / Prim Care 44 : 499 ~ 510
[학술지(정기간행물)] - Corn JE / 2014 / Ubiquitin in inflammation: the right linkage makes all the difference / Nat Struct Mol Biol 21 : 297 ~ 300
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UCI(KEPA) : I410-ECN-0101-2018-510-003599339