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논문 기본 정보

자료유형
학술저널
저자정보
한상훈 (연세대학교)
저널정보
대한의학회 Journal of Korean Medical Science Journal of Korean Medical Science Vol.33 No.23
발행연도
2018.1
수록면
1 - 2 (2page)

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Long pentraxin 3 (PTX3) is an acute phase reactant and one of the pattern recognition receptors (PRRs) binding a wide range of pathogen/damage associated molecular patterns (PAMP/ DAMP).1 It plays an important role in the innate immune system, like C-reactive protein (CRP), which is a short pentraxin synthesized in the liver and as an opsonin-activating classical complement pathway.2,3 The PTX3 is produced at a local inflammatory site by numerous cells including vascular endothelial cells, lung or tubular epithelial cells, mesangial cells, smooth muscle cells, synoviocytes, differentiating adipocytes, myeloid cells (especially neutrophil), monocytes, dendritic cells, and tumor cells.3 Because the PTX3 basically interacts with C1q of the first component of the classical complement cascade and can induce acute or chronic inflammation through heterogeneous cell types in many organ sites, it has the pleomorphic biological functions of a variety of medical fields including infectious disease including sepsis caused by bacteria, fungi or viruses (activation of microbes recognition and prompt innate immunity), cardiovascular diseases (endothelial dysfunction), metabolic diseases/ obesity, wound healing or tissue remodeling (fibrin degradation and matrix deposition), autoimmune inflammatory rheumatic diseases (recognition of self vs. non-self ), and cancers (anti-angiogenic or pro/anti-tumorogenic functions).2-6 The PTX3 has the different effects of promoting or inhibiting cancers according to the tumor cell type.4

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