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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2002.9
- 수록면
- 169 - 174 (6page)
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Resveratrol is known to have potent cancer chemopreventive activity against tumorigenesis caused by 7,12-dimethylbenz[α]anthracene (DMBA) which is known to be oxidized to reactive products by cytochrome P450 1B1 (CYP1B1). The effects of resveratrol on the activity of recombinant human P450 1 family enzymes, expressed in Escherichia coli membranes with human NADPH-P450 reductase, were determined by measuring alkoxyresorufin O-dealkylation activity, e.g., ethoxyresorufin O-deethylation (EROD) CYP1A1, methoxyresorufin O-demethylation (MROD), CYP1A2, benzyloxyresorufin-O-debenzylation (BROD), CYP1B1. Resveratrol
inhibited CYP1B1 and CYP1A1 activities in a dose-dependent manner with IC50 values of 59 and 10 μM for EROD activity and 1.8 and 30 μM for BROD activity, respectively. Resveratrol had only weak inhibitory effect on CYP1A2 activity (IC50 values of 0.44 mM for EROD and >2 mM for MROD). Furthermore, resveratrol did not affect NADPH-P450 reductase activity significantly. Resveratrol inhibited the CYP1B1-dependent EROD activity with a Ki of 28 μM in a non-competitive type manner. These results suggest that resveratrol-derived inhibition of CYP1B1 and CYP1A1 activities may contribute to the suppression of DMBA inducible tumorigenesis observed in extrahepatic tissues.
inhibited CYP1B1 and CYP1A1 activities in a dose-dependent manner with IC50 values of 59 and 10 μM for EROD activity and 1.8 and 30 μM for BROD activity, respectively. Resveratrol had only weak inhibitory effect on CYP1A2 activity (IC50 values of 0.44 mM for EROD and >2 mM for MROD). Furthermore, resveratrol did not affect NADPH-P450 reductase activity significantly. Resveratrol inhibited the CYP1B1-dependent EROD activity with a Ki of 28 μM in a non-competitive type manner. These results suggest that resveratrol-derived inhibition of CYP1B1 and CYP1A1 activities may contribute to the suppression of DMBA inducible tumorigenesis observed in extrahepatic tissues.
목차
ABSTRACT
Introduction
Materials and Methods
Results
Discussion
Acknowledgements
References
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UCI(KEPA) : I410-ECN-0101-2009-476-013751341