지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
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We investigated the anti-inflammatory effects of aqueous extract of Artemisia capillaris Thunb. (AEAC), a traditional Korean herb for remedying liver disease, for suppression in the process of lipopolysaccharide (LPS)-induced inflammation in the liver of rat. Level of glutamate oxaloacetate transaminase (GOT), glutamate pyruvate transaminase (GPT) and lactate dehydrogenase (LDH) was increased in the serum of LPS-treated rats compared to normal, however, in the rats pretreated with AEAC, the increase of GOT, GPT and LDH value was arrested. More severe histological changes of liver such as cloudy swelling, hydropic degeneration, Kupffer cell reaction and inflammatory cells infiltration were demonstrated in the rats challenged with LPS compared with normal. Fewer scores of these changes were observed in rats pretreated with AEAC. Immunohistochemical analysis showed that while the expression of the nuclear factor (NF)-κBp65, inducible nitric oxide synthase (iNOS), tumor necrosis factor (TNF)-α and COX (cyclooxygenase)-2 tended to increase, that of inhibitory (I)-κBα was decreased in the hepatocytes of rats challenged with LPS. A slight decline of NF-κBp65, TNF-α and COX-2, but increase of I-κBα were observed in the hepatocytes of the rats pretreated with AEAC. These results suggest that AEAC may act as a therapeutic agent for liver disease through a regulation of inflammation-related proteins.
목차
Abstract
재료 및 방법
결과
고찰
요약
감사의 글
참고문헌
참고문헌 (17)
참고문헌 신청
[학술지(정기간행물)] - / 1996 / LPS-mediated NF-kappa beta activation in rat Kupffer cells can be induced independently of CD14 270 : 956 ~ 961
[학술지(정기간행물)] - / 1999 / Protective effects of capillarisin on tert- butylhydroperoxide-induced oxidative damage in rat primary hepatocytes 73 : 263 ~ 268
[학술지(정기간행물)] - / 2001 / Transcriptional mechanisms of acute lung injury 281 : 1037 ~ 1050
[학술지(정기간행물)] - / 2002 / Nuclear transcription factor-kappaB as a target for cancer drug development 16 : 1053 ~ 1068
[학술지(정기간행물)] - / 2001185-194 / A decision between life and death during TNF-alpha-induced signaling 185 (l)
[학술지(정기간행물)] - / 1999 / Protective effects of capillarisin on tert- butylhydroperoxide-induced oxidative damage in rat primary hepatocytes 73 : 263 ~ 268
[학술지(정기간행물)] - / 2001 / Transcriptional mechanisms of acute lung injury 281 : 1037 ~ 1050
[학술지(정기간행물)] - / 2002 / Nuclear transcription factor-kappaB as a target for cancer drug development 16 : 1053 ~ 1068
[학술지(정기간행물)] - / 2001185-194 / A decision between life and death during TNF-alpha-induced signaling 185 (l)
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UCI(KEPA) : I410-ECN-0101-2009-470-014448085