지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Matrix metalloproteinases (MMPs) are a family of structurally and functionally related zinc-dependent enzymes responsible for proteolytic degradation of extracellular matrix components such as base membrane or interstitial stroma. MMPs play an important role in a variety of physiological and pathological tissue remodeling processes, including wound healing, embryo implantation, tumor invasion and metastasis. Since MMP-9 (gelatinase B) has unique ability to cleave type Ⅳ collagen, gene expression of MMP-9 has been focused on as a pharmacological target. Flavonoids are a class of compounds that are widely spread in plants. In the coures of screening for the suppressors of MMP-9 gene expression from natural products, Metasequoia glyptostroboides was selected. Six flavonoids, sciadopitysin, isoginkgetin, bilobetin, 2,3-dihydrohinokiflavone, luteolin and apigenin were purified as suppressors of MMP-9 gene expression from M. glyptostroboides. The suppressing activity of the isolated flavinoids on the MMP-9 gene expression was measured by gelatin zymography and Nothern blot analysis.
목차
Abstract
재료 및 실험방법
결과 및 고찰
요약
감사의 글
참고문헌
참고문헌 (18)
참고문헌 신청
Christelle Benaud, Rober B. Dickson, Erik W. Thompson. 1998. Roles of the matrix metalloproteinases in mammary gland development and cancer. Breast Cancer Research and Treatment 50, 97-116.
Clare M. Dollery, Jean R. McEwan, Adriano M. Henny. 1995. Matrix Metalloproteinases and Cardiovascular Disease. Circ Res. 77.
Hee Kee Kim, Kun Ho Son, Hyeun Wook Chang, Sam sik Kang, Hyun Pyo Kim. 1998. Amentoflavone, a Plant biflavone : A New Poteintial Anti-inflammatory Agent. Arch. Pharm. Res. Vol. 4, 406-410.
Hyun Sun Lee, Won Keun Oh, Bo Yeon Kim, Soon Cheol Ahn, Dae Ook Kang, et al., 1996. Inhibition of Phospholipase Cγ1 Activity by Amentoflavone isolated from Selaginella tarmariscina. Planta Medica 62, 293-296.
Ihn rhan Lee et al., 1992 Cytotoxicity of folklorie medicine in murine and human cancer cells. Kor. J. Pharmacogn. 23(3), 132-136.
Clare M. Dollery, Jean R. McEwan, Adriano M. Henny. 1995. Matrix Metalloproteinases and Cardiovascular Disease. Circ Res. 77.
Hee Kee Kim, Kun Ho Son, Hyeun Wook Chang, Sam sik Kang, Hyun Pyo Kim. 1998. Amentoflavone, a Plant biflavone : A New Poteintial Anti-inflammatory Agent. Arch. Pharm. Res. Vol. 4, 406-410.
Hyun Sun Lee, Won Keun Oh, Bo Yeon Kim, Soon Cheol Ahn, Dae Ook Kang, et al., 1996. Inhibition of Phospholipase Cγ1 Activity by Amentoflavone isolated from Selaginella tarmariscina. Planta Medica 62, 293-296.
Ihn rhan Lee et al., 1992 Cytotoxicity of folklorie medicine in murine and human cancer cells. Kor. J. Pharmacogn. 23(3), 132-136.
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UCI(KEPA) : I410-ECN-0101-2009-470-015374813