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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2009.1
- 수록면
- 453 - 461 (9page)
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초록· 키워드
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One of the 14-3-3 protein isoforms, 14-3-3ε, was previously
shown to be increased during skin aging. We
suggest here a possible role for the 14-3-3ε protein in
skin aging by providing evidence that 14-3-3ε increases
the expression of the matrix-metalloproteinase
(MMP)-2 gene in NIH3T3 fibroblast cells. Expression of
the 14-3-3ε gene in NIH3T3 cells primarily up-regulated
the expression of the MMP-2 gene at the transcriptional
level by inducing specific DNA binding proteins bound
to an upstream region of the MMP-2 promoter from
-1,629 to -1,612. Inhibition of endogenous 14-3-3ε gene
expression by RNA interference also decreased endogenous
MMP-2 gene expression. Furthermore,
up-regulation of the MMP-2 gene by 14-3-3ε was suppressed
by expression of a dominant-negative mutant
of p38 MAP kinase. These findings strongly suggest
that increased expression of 14-3-3ε contributes to remodeling
of extracellular matrix in skin through increasing
MMP-2 gene expression via p38 MAP kinase
signaling.
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등록된 정보가 없습니다.
참고문헌 (24)
참고문헌 신청
Brinckerhoff CE / 2002 / Matrix metalloproteinases: a tail of a frog that became a prince / Nat Rev Mol Cell Biol 3 : 207 ~ 214
Choi KC / 2005 / Increased expression of 14-3-3epsilon protein in intrinsically aged and photoaged human skin in vivo / Mech Ageing Dev 126 : 629 ~ 636
Chung JH / 2001 / Modulation of skin collagen metabolism in aged and photoaged human skin in vivo / J Invest Dermatol 117 : 1218 ~ 1224
Eun Jeong Lee / 2007 / Cyclooxygenase-2 promotes cell proliferation, migration andinvasion in U2OS human osteosarcoma cells / Experimental and Molecular Medicine 39 (4) : 46
Fisher GJ / 1996 / Molecular basis of sun-induced premature skin ageing and retinoid antagonism / Nature 379 : 335 ~ 339
Choi KC / 2005 / Increased expression of 14-3-3epsilon protein in intrinsically aged and photoaged human skin in vivo / Mech Ageing Dev 126 : 629 ~ 636
Chung JH / 2001 / Modulation of skin collagen metabolism in aged and photoaged human skin in vivo / J Invest Dermatol 117 : 1218 ~ 1224
Eun Jeong Lee / 2007 / Cyclooxygenase-2 promotes cell proliferation, migration andinvasion in U2OS human osteosarcoma cells / Experimental and Molecular Medicine 39 (4) : 46
Fisher GJ / 1996 / Molecular basis of sun-induced premature skin ageing and retinoid antagonism / Nature 379 : 335 ~ 339
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