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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2010.1
- 수록면
- 833 - 841 (9page)
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초록· 키워드
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Skin exposure to low-dose ultraviolet B (UVB) light up-regulates the expression of matrix metalloproteinase-1 (MMP-1), thus contributing to premature skin aging (photo-aging). Although cyclooxygenase-2 (COX-2) and its product, prostaglandin E2 (PGE2), have been associated with UVB-induced signaling to MMP expression,very little are known about the roles of lipoxygenases and their products, especially leukotriene B4 (LTB4) and 12(S)-hydroxyeicosatetraenoic acid (12(S)-HETE), in MMP-1 expression in skin keratinocytes.
In the present study, we demonstrate that BLT2,a cell surface receptor for LTB4 and 12(S)-HETE, plays a critical role in UVB-mediated MMP-1 upregulation in human HaCaT keratinocytes. Moreover, our results demonstrated that BLT2-mediated MMP-1 upregulation occurs through a signaling pathway dependent on reactive oxygen species (ROS) production and the subsequent stimulation of ERK. Blockage of BLT2via siRNA knockdown or with the BLT2-antagonist LY255283 completely abolished the up-regulated expression of MMP-1 induced by low-dose UVB irradiation.
Finally, when HaCaT cells were transiently transfected with a BLT2 expression plasmid, MMP-1expression was significantly enhanced, along with ERK phosphorylation, suggesting that BLT2 overexpression alone is sufficient for MMP-1 up-regulation.
Together, our results suggest that the BLT2-ROSERK-linked cascade is a novel signaling mechanism for MMP-1 upregulation in low-dose UVB- irradiated keratinocytes and thus potentially contributes to photo-aging.
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참고문헌 (24)
참고문헌 신청
Brenneisen P / 2002 / Ultraviolet-B irradiation and matrix metalloproteinases: from induction via signaling to initial events / Ann N Y Acad Sci 973 : 31 ~ 43
Choi JA / 2008 / Reactive oxygen species are generated through a BLT2-linked cascade in Ras-transformed cells / Free Radic Biol Med 44 : 624 ~ 634
El-Abaseri TB / 2005 / Chemoprevention of UV light-induced skin tumorigenesis by inhibition of the epidermal growth factor receptor / Cancer Res 65 : 3958 ~ 3965
Faustin B / 2008 / Sunburned skin activates inflammasomes / Trends Cell Biol 18 : 4 ~ 8
Fisher GJ / 1996 / Molecular basis of sun-induced premature skin ageing and retinoid antagonism / Nature 379 : 335 ~ 339
Choi JA / 2008 / Reactive oxygen species are generated through a BLT2-linked cascade in Ras-transformed cells / Free Radic Biol Med 44 : 624 ~ 634
El-Abaseri TB / 2005 / Chemoprevention of UV light-induced skin tumorigenesis by inhibition of the epidermal growth factor receptor / Cancer Res 65 : 3958 ~ 3965
Faustin B / 2008 / Sunburned skin activates inflammasomes / Trends Cell Biol 18 : 4 ~ 8
Fisher GJ / 1996 / Molecular basis of sun-induced premature skin ageing and retinoid antagonism / Nature 379 : 335 ~ 339
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