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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2009.1
- 수록면
- 259 - 268 (10page)
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초록· 키워드
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Matrix metalloproteinase-9 (MMP-9) secreted from
macrophages plays an important role in tissue destruction
and inflammation through degradation of
matrix proteins and proteolytic activation of cytokines/
chemokines. Whereas the MEK-ERK and PI3KAkt
pathways up-regulate MMP-9 expression, regulation
of MMP-9 by JNK remains controversial. Presently,
we aimed to determine the role of JNK in MMP-9
regulation in Raw 264.7 cells. Inhibition of JNK by the
JNK inhibitor SP600125 induced MMP-9 in the absence
of serum and suppressed the expression of TNF-α, IL-6
and cyclooxygenase-2 in LPS-treated Raw 264.7 cells.
In a knockdown experiment with small interfering RNA,
suppression of JNK1 induced MMP-9 expression.
Interestingly, mouse serum suppressed SP600125-
mediated MMP-9 induction, similar to IFN-γ. However,
the inhibitory activity of mouse serum was not affected
by pyridone 6, which inhibits Janus kinase downstream
to IFN-γ. In addition to mouse serum, conditioned
media of Raw 264.7 cells contained the inhibitory
factor(s) larger than 10 kDa, which suppressed
SP600125- or LPS-induced MMP-9 expression. Taken
together, these data suggest that JNK1 suppresses
MMP-9 expression in the absence of serum. In addition,
the inhibitory factor(s) present in serum or secreted
from macrophages may negatively control MMP-9
expression.
목차
등록된 정보가 없습니다.
참고문헌 (21)
참고문헌 신청
Arai K / 2003 / Essential role for ERK mitogenactivated protein kinase in matrix metalloproteinase-9 regulation in rat cortical astrocytes / Glia 43 : 254 ~ 264
Atkinson JJ / 2003 / Matrix metalloproteinase-9 in lung remodeling / Am J Respir Cell Mol Biol 28 : 12 ~ 24
Benbow U / 1997 / Brinckerhoff CE. The AP-1 site and MMP gene regulation: what is all the fuss about? / Matrix Biol 15 : 519 ~ 526
Blom AB / 2007 / Crucial role of macrophages in matrix metalloproteinase-mediated cartilage destruction during experimental osteoarthritis: involvement of matrix metalloprote
Bogoyevitch MA / 2006 / The isoform-specific functions of the c-Jun N-terminal Kinases (JNKs): differences revealed by gene targeting / Bioessays 28 : 923 ~ 934
Atkinson JJ / 2003 / Matrix metalloproteinase-9 in lung remodeling / Am J Respir Cell Mol Biol 28 : 12 ~ 24
Benbow U / 1997 / Brinckerhoff CE. The AP-1 site and MMP gene regulation: what is all the fuss about? / Matrix Biol 15 : 519 ~ 526
Blom AB / 2007 / Crucial role of macrophages in matrix metalloproteinase-mediated cartilage destruction during experimental osteoarthritis: involvement of matrix metalloprote
Bogoyevitch MA / 2006 / The isoform-specific functions of the c-Jun N-terminal Kinases (JNKs): differences revealed by gene targeting / Bioessays 28 : 923 ~ 934
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