지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2006.1
- 수록면
- 79 - 83 (5page)
이용수
초록· 키워드
오류제보하기
Tissue plasminogen activator (tPA) is used to lyse clots and reperfuse brain in ischemic stroke. However, sideeffects of intracerebral hemorrhage (ICH) and edema limit their clinical application. In part, these phenomena has been linked with elevations in matrix metalloproteinase-9 (MMP-9) in neurovascular unit. However little is known about their regulatory signaling pathways in brain cells. Here, I examine the role of MAP kinase pathways in tPA-induced MMP-9 regulation in rat cortical astrocytes. tPA $(1-10\;{\mu}g/ml)$ induced dose-dependent elevations in MMP-9 and MMP-2 in conditioned media. Although tPA increased phosphorylation in two MAP kinases (ERK, JNK), only inhibition of the JNK pathway by the JNK inhibitor SP600126 significantly reduced MMP-9 upregulation. Neither ERK inhibition with U0126 nor p38 inhibition with SB203580 had any significant effects. Taken together, these results suggest that c-jun N-terminal kinase (JNK) plays an essential role for tPA-induced MMP-9 upregulation.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
뇌신경세포에서 tPA에 의한 MMP의 발현 조절에 관한 연구
생명과학회지
2009 .06
-
Regulation of expression of matrix metalloproteinase-9 by JNK in Raw 264.7 cells: presence of inhibitory factor(s) suppressing MMP-9 induction in serum and conditioned media
Experimental and Molecular Medicine
2009 .01
-
Protein Kinase A Functions as a Negative Regulator of c-Jun N-terminal Kinase but not of p38 Mitogen-activated Protein Kinase in PC12 Cells
Integrative biosciences
2005 .01
-
Transcription of the protein kinase C-δ gene is activated by JNK through c-Jun and ATF2 in response to the anticancer agent doxorubicin
Experimental and Molecular Medicine
2008 .01
-
SP600125, a selective JNK inhibitor, aggravates hepatic ischemia-reperfusion injury
Experimental and Molecular Medicine
2006 .01
-
Induction of tissue inhibitor of matrix metalloproteinase-2 by cholesterol depletion leads to the conversion of proMMP-2 into active MMP-2 in human dermal fibroblasts
Experimental and Molecular Medicine
2010 .01
-
3D-QSAR Studies of 3,5-disubstituted Quinolines Inhibitors of c-Jun N-terminal Kinase-3
조선자연과학논문집
2011 .01
-
Conformational changes of JNK3 splice variants upon ATP binding
Biodesign
2019 .01
-
녹차 (-)EGCG에 의한 사람 폐암 세포주 A549의 c-Jun N-terminal Kinase 1과 Activating Protein-1활성화를 통한 세포고사
한국영양학회지
2002 .01
-
Fucoxanthin derivatives from Sargassum siliquastrum inhibit matrix metalloproteinases by suppressing NF-κB and MAPKs in human fibrosarcoma cells
Algae
2014 .01
-
14-3-3ε protein increases matrix metalloproteinase-2 gene expression via p38 MAPK signaling in NIH3T3 fibroblast cell
Experimental and Molecular Medicine
2009 .01
-
A functional comparison between the HER2high/HER3 and the HER2low/HER3 dimers on heregulin-β1-induced MMP-1 and MMP-9 expression in breast cancer cells
Experimental and Molecular Medicine
2012 .01
-
Methyl Linderone Suppresses TPA-Stimulated IL-8 and MMP-9 Expression Via the ERK/STAT3 Pathway in MCF-7 Breast Cancer Cells
Journal of Microbiology and Biotechnology
2020 .01
-
Matrix Metalloproteinase: Inhibitory Effect of Marine Substances on MMP-2 and MMP-9
조선자연과학논문집
2011 .01
-
Design of Novel JNK3 Inhibitors Based on 3D-QSAR In Silico Model
조선자연과학논문집
2012 .01
-
Comparison of Effects between Alteplase and Pamiteplase on MMPs Regulation
생명과학회지
2007 .07
-
Extracellular HIV-1 Tat up-regulates expression of matrix metalloproteinase-9 via a MAPK-NF-κB dependent pathway in human astrocytes
Experimental and Molecular Medicine
2009 .01
-
참당귀 추출분말이 in vitro and in vivo model에서 MMPs 조절 기전
분석과학
2015 .12
-
헛개나무내의 Matrix Metalloproteinase-9 활성 억제제에 관한 연구
분석과학
2011 .04
-
Genistein Suppresses TPA-Induced Matrix Metalloproteinases Activity and Cell Invasion in Human Breast Adenocarcinoma Cells
생명과학회지
2012 .07
이 논문의 저자 정보
최근 본 자료
댓글(0)
0