지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
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Human Disabled-2 (Dab2) is a candidate tumor suppressor gene that regulates cell growth by c-Fos suppression in normal cells. In many cancer cells, Dab2 expression is lost or greatly diminished in ～85% of the breast and ovarian cancers. In this study, we have examined the methylation status of CpG island on Dab2 gene promoter using bisulfite-assisted genomic sequencing and methylation specific PCR (MSP) method in human breast cancer cell line, MDA MB-231 cells. In normal human uterus endometrial cells, Dab2 was completely unmethylated. In contrast, Dab2 was methylated on CpG dinucleotides near the TATA box in MDA MB-231 cells. Following MDA MB-231 cells by treatment with 5-azacytidine, Dab2 gene were demethylated and reexpressed. Result of this study suggested that silencing of Dab2 gene is correlated to CpG island methylation in human breast cancer cell line, MBA MD-231 cells.
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Abstract
재료 및 방법
결과
고찰
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감사의 글
참고문헌
참고문헌 (28)
참고문헌 신청
Antequera, F., J. Boyes and A. Bird. 1990. High levels of de novo methylation and altered chromatin structure at CpG islands in cell lines. Cell 62, 503-514.
Beard, C., E. Li and R. Jaenisch. 1995. Loss of methylation activates Xist in somatic but not in embryonic cells. Genes Dev. 9, 2325-2334.
Becker, P. B., S. Ruppert and G. Schutz. 1987. Genomic footprinting. reveals cell type-specific DNA binding of ubiquitous factors. Cell 51, 435-443.
Berger, J. and G. Daxenbichler. 2002. DNA methylation of nuclear receptor genes-possible role in malignancy. J Steroid Biochem. Mol. Biol. 80, 1-11.
Bird, A. 1992. The essentials of DNA methylation. Cell 70, 5-8.
Beard, C., E. Li and R. Jaenisch. 1995. Loss of methylation activates Xist in somatic but not in embryonic cells. Genes Dev. 9, 2325-2334.
Becker, P. B., S. Ruppert and G. Schutz. 1987. Genomic footprinting. reveals cell type-specific DNA binding of ubiquitous factors. Cell 51, 435-443.
Berger, J. and G. Daxenbichler. 2002. DNA methylation of nuclear receptor genes-possible role in malignancy. J Steroid Biochem. Mol. Biol. 80, 1-11.
Bird, A. 1992. The essentials of DNA methylation. Cell 70, 5-8.
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UCI(KEPA) : I410-ECN-0101-2009-470-015375734