지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2005.9
- 수록면
- 259 - 266 (8page)
이용수
초록· 키워드
오류제보하기
Mast cells and goblet cells have been blown to protect the host against parasites. In this study, we examined the response of the mast cells and goblet cells over a period of 6 weeks in the duodenum, jejunum and ileum of C3H/HeN and C57BL/6 mice infected with Echinostoma hortense(E.hortense). In addition, we investigated whether the worm recovery rate of uninfected mice (the control poop) or E. hortense-infected mice (the experimental group) was associated with the number of mast cells and goblet cells. The worm recovery rate was higher in the C3H/HeN mice than in the C57BL/6 mice. The number of goblet cells significantly increased in the experimental group of the C3H/HeN and C57BL/6 mice compared with the control group of both strains (p＜0.005). Worm recovery peaked 3 weeks after the infection of the C57BL/6 mice and at 2 weeks after the infection of the C3H/HeN mice, and it was higher in the duodenum than in the jejunum and ileum. However, the infected site in the intestine had no relation with worm expulsion. In the C3H/HeN and C57BL/6 mice, the number of goblet cells in the experimental group was significantly higher than that in the control poop (P＜0.005). The number reached a peak 2 weeks after the infection and it even increased in duodenum, jejunum and ileum. The increased number of goblet cells was retained 6 weeks after infection. The number of goblet cells was higher in the C3H/HeN mice than in the C57BL/6 mice (P＜0.01). These results indicate that goblet cells are related with the worm expulsion. Furthermore, immunohistostaining of the antral intestinal walls for lectin showed the significant increase of the number of goblet cells in the experimental group (P＜0.001). The high infection rate in the duodenum was found during the early infection. An increased infection rate in the jejunum and ileum was found 3 weeks after infection and the infection rate was higher in the C3H/HeN mice than in the C57BL/6 mice. Taken together, the present study indicates that goblet cells, rather than mast cells, may play critical roles in parasite expulsion.
목차
영어초록
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (24)
참고문헌 신청
[학술지(정기간행물)] - T, Abe / 1992 / Induction of the expulsion of Strongyloides ratti and retention of Nippostrongylus brasiliensis in athymic nude mice by repetitive administration of recombinant IL-3. / Immunology 76 : 10 ~ 14
[학술지(정기간행물)] - T, Abe / 1993 / Diffrent susceptibility to the IL-3 induced protective effects between Strongyloides ratti and Nippostrongylus brasiliensis in C57BL/6 mice / Parasitol Immunol. 15 : 643 ~ 645
[학술지(정기간행물)] - KE, Barrett / 1988 / The immune response to nematode parasites of mast cell numbers and function during stongyloides stercoralis infections in nonhuman primates / Am J Trop Med Hyg. 38 (3) : 574 ~ 581
[학술지(정기간행물)] - SM,Carroll / 1984 / Kinetics of intestinal lamina propria mast cells, globule leucocytes, intraepithelial lymphocytes, goblet cells and eosinophils in murine strongyloidiasis / Int Arch Allergy Appl Immunol. 74 : 311 ~ 317
[학술지(정기간행물)] - JY, Chai / 1993 / Mucosal mast cell responses to experomental Metagonimus yokogawai infection in rats / Korean J Parasitol 31 (2) : 129 ~ 134
[학술지(정기간행물)] - T, Abe / 1993 / Diffrent susceptibility to the IL-3 induced protective effects between Strongyloides ratti and Nippostrongylus brasiliensis in C57BL/6 mice / Parasitol Immunol. 15 : 643 ~ 645
[학술지(정기간행물)] - KE, Barrett / 1988 / The immune response to nematode parasites of mast cell numbers and function during stongyloides stercoralis infections in nonhuman primates / Am J Trop Med Hyg. 38 (3) : 574 ~ 581
[학술지(정기간행물)] - SM,Carroll / 1984 / Kinetics of intestinal lamina propria mast cells, globule leucocytes, intraepithelial lymphocytes, goblet cells and eosinophils in murine strongyloidiasis / Int Arch Allergy Appl Immunol. 74 : 311 ~ 317
[학술지(정기간행물)] - JY, Chai / 1993 / Mucosal mast cell responses to experomental Metagonimus yokogawai infection in rats / Korean J Parasitol 31 (2) : 129 ~ 134
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UCI(KEPA) : I410-ECN-0101-2009-510-017356558