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한국식품영양과학회 Journal of Food Science and Nutrition Journal of Food Science and Nutrition Vol.12 No.1
발행연도
2007.3
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16 - 22 (7page)

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In order to evaluate the hepatoprotective effect of an herb distillate, ie., a mixture of 28 traditional Korean herbs, germanium, tormarine and Gijangsoo (Gijang water), CCl₄ was intraperitoneally administered to rats before or after supplementation of the diluted herb distillate (HD) for 2 weeks. Then hepatic xanthine oxidase activity and serum lipid profiles were determined. The experimental groups had higher feed intake than the normal control (NC), but had lower weight gain. Water intake and the amount of feces were not significantly different, but urine was excreted in lower amounts in all the experimental groups compared to the NC. Liver weights in the HD-supplemented groups were lower than that of the distilled water-supplemented groups (DW-groups) after CCl4-administration. Serum ALT activities in all the experimental groups were higher than that of the NC-group. However, the increasing activity of serum ALT in the HD-supplemented groups (HD-groups) was lower than that of the DW-groups. Total serum and LDL-cholesterol levels were higher in all the CCl₄-administered groups than in the NC-groups, and serum HDL-cholesterol levels were lower in all the experimental groups compared with the NC-groups. Meanwhile, the increasing rate of total serum and LDL-cholesterol levels and the decreasing rate of HDL-cholesterol in the HD-groups were lower than that of the DW-groups. But, levels of serum TG were similar among all the experimental groups. The activities of hepatic xanthine oxidase (XOD) type O of the CCl4-administered rats showed a significant increase in and an increasing rate of XOD in the HD-groups, which was lower than that of the DW-groups. On the other hand, GST activities in all the experimental groups were significantly decreased, and the decreasing rate was lower in the HD-groups than in the DW-groups. The hepatic contents of GSH and LPO in all the rats were not changed by CCl4 administration. These results suggest that the decreased liver damage in the HD-supplemented groups was due to the inhibition of XOD-type O activity by constituents of HD, as well as by a prevention/inhibition of serum lipid profile changes in CCl₄-treated rats. However, further detailed studies are needed to support this hypothesis.
#herb distillate #carbon tetrachloride #xanthine oxidase activity #hepatic lipid profiles

목차

Abstract
INTRODUCTION
MATERIALS AND METHODS
RESULTS AND DISCUSSION
REFERENCES

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Marieb EN. 1998. Human Anantomy & Physiology. 4 ed. Benjamin/Cummimgs Science Publishing, California, USA. p 1006-1007. google schola Park JH, Jin JH, Kim HJ, Park HR, Lee SC. 2005. Effect of far-infrared irradiation on the antioxidant activity of extracts from rice hulls. J Korean Soc Food Sci Nutr 34: 131-134. google schola Lee CW, Jeong WI, Noh DH, Jeong DH, Do SH, Kim YK, Kwon OD, Kim TH, Jeong KS. 2005. Protective effects of bio-active ceramic water on alcohol-induced hepatic injury in pigs. J Vet Med Sci 67: 403-409. google schola Kim EJ, Lee KI, Park KY. 2004. The growth inhibition against gastric cancer cell in germanium or soybean sprouts cultured with germanium. Korean J Soc Food Cookery Sci 20: 287-291. google schola Yoo BH, Park CM, Oh TJ, Han SH, Kang HH, Chang IS. 2002. Investigation of jewelry powders radiating far-infrared rays and the biological effects on human skin. J Cosmet Sci 53: 175-184. google schola

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