지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2007.6
- 수록면
- 135 - 142 (8page)
이용수
초록· 키워드
오류제보하기
Formononetin is an isoflavonoid phytoestrogen found in certain foodstuffs such as soy and red clover. In this study, we examined the action of formononetin with the carcinogen activation pathway mediated through the aryl hydrocarbon receptor (AhR) in MCF-7 breast carcinoma cells. Treating the cells with formononetin alone caused the accumulation of CYP1A1 mRNA as well as elevation in CYP1A1-specific 7-ethoxyresorufin O-deethylase (EROD) activity in a dose dependent manner. However, a concomitant treatment with 7,12-dimethylbenz[a]anthracene (DMBA) and formononetin markedly reduced both the DMBA-inducible EROD activity and CYP1A1 mRNA level. Under the same conditions, formononetin inhibited the DMBA-induced AhR transactivation, as shown by reporter gene analysis using a xenobiotic responsive element (XRE). Additionally, formononetin inhibited both DMBA-inducible nuclear localization of the aryl hydrocarbon receptor (AhR) and metabolic activation of DMBA, as measured by the formation of the DMBA-DNA adducts. Furthermore, formononetin competed with the prototypical AhR ligand, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), for binding to the AhR in an isolated rat cytosol. These results suggest that formononetin might be considered as a natural ligand to bind on AhR and consequently produces a potent protective effect against DMBA-induced genotoxicity. Therefore, that’s the potential to act as a chemopreventive agent that is related to its effect on AhR pathway as antagonist/agonist.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
ACKNOWLEDGMENTS
REFERENCES
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Effect of Biochanin A on the Aryl Hydrocarbon Receptor and Cytochrome P450 1A1 in MCF-7 Human Breast Carcinoma Cells
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
2006 .01
-
Up-regulating of RASD1 and Apoptosis of DU-145 Human Prostate Cancer Cells Induced by Formononetin in Vitro
Asian Pacific journal of cancer prevention : APJCP
2014 .01
-
Daidzein Modulates Induction of Hepatic CYP1A1, 1B1, and AhR by 7,l2-dimethylbenz[a]anthracene in Mice
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
2008 .01
-
Identification and Functional Characterization of Two Aryl Hydrocarbon Receptors (AHR1 and AHR2) in Carassius auratus
환경독성보건학회 심포지엄 및 학술대회
2004 .05
-
Effect of Genistein on the Aryl Hydrocarbon Receptor and Cytochrome P450 1A1 in MCF-7 Human Breast Carcinoma Cells
Environmental Analysis Health and Toxicology
2006 .03
-
Analysis of Gene Expression Modulated by Indole-3-carbinol in Dimethylbenz[a]anthracene-induced Rat Mammary Carcinogenesis
Molecular & cellular toxicology
2009 .01
-
In Vitro Transactivation Potencies of Red Seabream(Pagrus major ) AHR1 and AHR2 by Dioxins
환경독성보건학회 심포지엄 및 학술대회
2012 .05
-
cDNA cloning and characterization of two aryl hydrocarbon receptors(ahr1 and ahr2) from goldfish(Carassius auratus)
환경독성보건학회 심포지엄 및 학술대회
2004 .11
-
7 , 12-dimethylbenz[a]anthracene ( DMBA ) 투여에 의한 랫드 유선암 모델에서 ex - vivo 면역치료 효과 ( Effects of the ex-vivo Immunotherapy on the Mammary Gland Tumorigenesis Induced by 7 , 12-dimethylbenz{a}anthracene ( DMBA ) in rats )
Toxicological Research
1998 .12
-
Endosulfan Induces CYP1A1 Expression Mediated through Aryl Hydrocarbon Receptor Signal Transduction by Protein Kinase C
Toxicological Research
2015 .12
-
P-6. Pathological Observation and DNA Ploidy Patterns of Mammary Tumors Induced by 7.12-dimethylbenz[a]anthracene (DMBA) in Rats
한국실험동물학회 학술발표대회 논문집
1993 .10
-
Regulation of CYP 1A1 gene expression by retinoic acid receptor, retinoid X receptor and constitutive androstane receptor in rainbow trout hepatoma cells(RTH 149)
대한약학회 학술대회
2003 .01
-
ARYL HYDROCARBON- AND ESTROGEN-MEDIATED SIGNALS POSSIBLY CROSS TALK TO REGULATE CYP1A1 GENE EXPRESSION
한국응용약물학회 추계학술발표논문집
2001 .01
-
DMBA 매식과 방사선 조사로 유도된 백서 타액선 종양에서 H-ras 암유전자의 활성화
치과방사선
1998 .01
-
Chemopreventive Potential of Coumarin in 7,12-dimethylbenz[a] anthracene Induced Hamster Buccal Pouch Carcinogenesis
Asian Pacific journal of cancer prevention : APJCP
2012 .01
-
메타콜린과 운동 유발 기관지 수축반응의 상관관계에 대한 종단적 연구
대한내과학회지
2009 .01
-
Bioassays of Polycyclic Aromatic Hydrocarbons using CYP1A1-luciferase Reporter Gene Expression System in Human Breast Cancer MCF-7 Cells
한국환경성돌연변이·발암원학회지
2003 .06
-
황기추출물의 항노화 효과
대한화장품학회지
2007 .01
-
DMBA 유발흰쥐 유방암에서 실온노출시간에 따른 에스트로젠 수용체 함량의 변화
Annals of Surgical Treatment and Research
1991 .07
이 논문의 저자 정보
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-ECN-0101-2009-513-016821091