지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.12
- 수록면
- 339 - 345 (7page)
이용수
초록· 키워드
오류제보하기
CYP1A1 is a phase I xenobiotic-metabolizing enzyme whose expression is mainly driven by AhR. Endosulfan is an organochlorine pesticide used agriculturally for a wide range of crops. In this study, we investigated the effect of endosulfan on CYP1A1 expression and regulation. Endosulfan significantly increased CYP1A1 enzyme activity as well as mRNA and protein levels. In addition, endosulfan markedly induced XRE transcriptional activity. CH-223191, an AhR antagonist, blocked the endosulfan-induced increase in CYP1A1 mRNA and protein expression. Moreover, endosulfan did not induce CYP1A1 gene expression in AhR-deficient mutant cells. Furthermore, endosulfan enhanced the phosphorylation of calcium calmodulin (CaM)-dependent protein kinase (CaMK) and protein kinase C (PKC). In conclusion, endosulfaninduced up-regulation of CYP1A1 is associated with AhR activation, which may be mediated by PKCdependent pathways.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (27)
참고문헌 신청
Nelson, D. R. / 1996 / P450 superfamily: update on new sequences, gene mapping, accession numbers and nomenclature / Pharmacogenetics 6:1~42
Dipple, A. / 1994 / Reactions of polycyclic aromatic hydrocarbons with DNA / IARC Sci. Publ. 125:107~129
Han, E. H. / 2009 / Up-regulation of CYP1A1 by rutaecarpine is dependent on aryl hydrocarbon receptor and calcium / Toxicology 266:38~47
Denis, M. / 1988 / Association of the dioxin receptor with the Mr 90,000 heat shock protein: a structural kinship with the glucocorticoid receptor / Biochem. Biophys. Res. Commun. 155:801~807
Perdew, G. H. / 1988 / Association of the Ah receptor with the 90-kDa heat shock protein / J. Biol. Chem. 263:13802~13805
Dipple, A. / 1994 / Reactions of polycyclic aromatic hydrocarbons with DNA / IARC Sci. Publ. 125:107~129
Han, E. H. / 2009 / Up-regulation of CYP1A1 by rutaecarpine is dependent on aryl hydrocarbon receptor and calcium / Toxicology 266:38~47
Denis, M. / 1988 / Association of the dioxin receptor with the Mr 90,000 heat shock protein: a structural kinship with the glucocorticoid receptor / Biochem. Biophys. Res. Commun. 155:801~807
Perdew, G. H. / 1988 / Association of the Ah receptor with the 90-kDa heat shock protein / J. Biol. Chem. 263:13802~13805
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UCI(KEPA) : I410-ECN-0101-2016-513-002331436