지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2009.3
- 수록면
- 71 - 77 (7page)
이용수
초록· 키워드
오류제보하기
Adenoviral vector (AdV) has been the most widely used viral vector for delivering an exogenous therapeutic gene to human. As of this date, more clinical trials utilize recombinant AdV to treat cancer and monogenic inherited disease as well as vaccine applications. However, the number of clinical trials had dropped markedly following the tragic death of a patient ongoing an AdV therapy for the treatment of an ornithine transcarbamylase deficiency (OTCD). This review is an attempt to provide the information on toxicity generated by AdV-mediated gene transfer. It would serve as a sobering reality to researchers and clinicians exploring the use of AdV, as to the complications involved in human application.
목차
ABSTRACT
서론
본론
결론
Abbreviations
감사의 글
참고문헌
참고문헌 (26)
참고문헌 신청
1. [학술지(정기간행물)] - Bergelson JM / 1997 / Isolation of a common receptor for cosackie B viruses and adenoviruses 2 and 5 / Science 275 (5304) : 1320 ~ 1323
2. [학술지(정기간행물)] - Boquet MP / 2008 / Influence of method of systemic administration of adenovirus on virusmediated toxicity: focus on mortality, virus distribution, and drug metabolism / J Pharmacol Toxicol Methods 58 (3) : 222 ~ 232
3. [학술지(정기간행물)] - Dewey RA / 1999 / Chronic brain inflammation and persistent herpes simplex virus 1 thymidine kinase expression in survivors of syngeneic glioma treated by adenovirus-mediated gene therapy: implications for clinical trials / Nat Med 5 : 1256 ~ 1263
4. [학술지(정기간행물)] - Dormond E / 2009 / From the first to the third generation adenoviral vector: What parameters are governing the production yield? / Biotechnol Advances 27 (2) : 133 ~ 144
5. [학술지(정기간행물)] - Driesse MJ / 1998 / Intracerebral injection of adenovirus harboring the HSVtk gene combined with ganciclovir administration: toxicity study in nonhuman primates / Gene Ther 5 : 1122 ~ 1129
2. [학술지(정기간행물)] - Boquet MP / 2008 / Influence of method of systemic administration of adenovirus on virusmediated toxicity: focus on mortality, virus distribution, and drug metabolism / J Pharmacol Toxicol Methods 58 (3) : 222 ~ 232
3. [학술지(정기간행물)] - Dewey RA / 1999 / Chronic brain inflammation and persistent herpes simplex virus 1 thymidine kinase expression in survivors of syngeneic glioma treated by adenovirus-mediated gene therapy: implications for clinical trials / Nat Med 5 : 1256 ~ 1263
4. [학술지(정기간행물)] - Dormond E / 2009 / From the first to the third generation adenoviral vector: What parameters are governing the production yield? / Biotechnol Advances 27 (2) : 133 ~ 144
5. [학술지(정기간행물)] - Driesse MJ / 1998 / Intracerebral injection of adenovirus harboring the HSVtk gene combined with ganciclovir administration: toxicity study in nonhuman primates / Gene Ther 5 : 1122 ~ 1129
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Production and Quality Control of Adenoviral Vectors for Clinical Trials
JOURNAL OF BACTERIOLOGY AND VIROLOGY
2008 .12
-
Antiviral efficacies of currently available rescue therapies for multidrug-resistant chronic hepatitis B
Clinical and Molecular Hepatology
2013 .01
-
저용량 adefovir dipivoxil에 의한 저인산염혈증과 다발성 근육통 1예
대한내과학회지
2010 .01
-
Current Status of the Clinical Development of Gene Therapy
대한의생명과학회지
2018 .09
-
Rescue therapy with adefovir in decompensated liver cirrhosis patients with lamivudine-resistant hepatitis B virus
Clinical and Molecular Hepatology
2014 .01
-
Validation of prognostic impact of ADV score for resection of hepatocellular carcinoma: analysis using Korea Liver Cancer Registry Database
Annals of Surgical Treatment and Research
2020 .05
-
Molecular Imaging of Biological Gene Delivery Vehicles for Targeted Cancer Therapy: Beyond Viral Vectors
Nuclear medicine and molecular imaging : NMMI
2010 .01
-
Virologic response is not durable after adefovir discontinuation in lamivudine-resistant chronic hepatitis B patients
Clinical and Molecular Hepatology
2011 .01
-
Management of Clevudine-Resistant Chronic Hepatitis B: A Multicenter Cohort Study
Gut and Liver
2017 .01
-
Fanconi’s Syndrome Associated with Prolonged Adefovir Dipivoxil Therapy in a Hepatitis B Virus Patient
Gut and Liver
2010 .01
-
Efficacy of switching from adefovir to tenofovir in chronic hepatitis B patients who exhibit suboptimal responses to adefovir-based combination rescue therapy due to resistance to nucleoside analogues (SATIS study)
Clinical and Molecular Hepatology
2016 .01
-
암 유전자 치료제의 개발 현황
Toxicological Research
2003 .09
-
Gene Therapy for Ischemic Diseases Adenoviral-Mediated Delivery of Early Growth Response Factor-1 Gene Increases Tissue Perfusion in a Murine Model of Hindlimb Ischemia
대한핵의학회 학술대회
2006 .01
-
Gene Therapy
대한수의사회지
1996 .01
-
Long-term outcomes of two rescue therapies in lamivudine- refractory patients with chronic hepatitis B: combined lamivudine and adefovir, and 1-mg entecavir
Clinical and Molecular Hepatology
2014 .01
-
Recent advances in the development of gene delivery systems
생체재료학회지
2019 .01
-
Cancer Gene Therapy : Chemosensitization by an Enzyme-Prodrug Activation Strategy
한국응용약물학회 추계학술발표논문집
1997 .01
이 논문의 저자 정보
이 논문과 함께 이용한 논문
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-ECN-0101-2009-539-019521218