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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2008.12
- 수록면
- 167 - 172 (6page)
이용수
초록· 키워드
오류제보하기
The importance of recombinant adenoviral vectors for the development of gene therapy and prophylactic and therapeutic vaccines has led to efforts for process development of large scale production of clinically safe adenoviral vectors. First of all, cell lines producing replication incompetent adenoviral vectors required for clinical application have been developed and the concept of banking and characterization of cell lines and adenoviral vectors has been established. In order to meet the need of amount of adenoviral vectors for clinical trials, various large scale suspension culture methods using serum-free media have been developed along with development of large scale purification methods using chromatography instead of cesium chloride method. In addition, methods for the quality control of adenoviral vectors have been established and applied for the clinical lots.
목차
서론
1. 재조합 아데노바이러스 생산용 세포주
2. 재조합 아데노바이러스 생산
3. 재조합 아데노바이러스 품질관리
결론 및 고찰
참고문헌
참고문헌 (15)
참고문헌 신청
1. [학술지(정기간행물)] - Barouch DH / 2005 / Adenovirus vector-based vaccines for human immunodeficiency virus type 1 / Hum Gene Ther 16 : 149 ~ 156
2. [학술지(정기간행물)] - Blanche F / 2000 / An improved anion¬exchange HPLC method for the detection and purification of adenoviral particles / Gene Ther 7 : 1055 ~ 1062
3. [학술지(정기간행물)] - Boyer JL / 2005 / Adeno- virus based genetic vaccines for biodefence / Hum Gene Ther 16 : 157 ~ 168
4. [학술지(정기간행물)] - Croyle MA / 1998 / Development of a highly efficient purification process for recombinant adenoviral vectors for oral gene delivery / Pharm Dev Technol 3 : 365 ~ 372
5. [학술지(정기간행물)] - Danthinne X / 2000 / Production of first generation adenovirus vectors: a review / Gene Ther 7 : 1707 ~ 1714
2. [학술지(정기간행물)] - Blanche F / 2000 / An improved anion¬exchange HPLC method for the detection and purification of adenoviral particles / Gene Ther 7 : 1055 ~ 1062
3. [학술지(정기간행물)] - Boyer JL / 2005 / Adeno- virus based genetic vaccines for biodefence / Hum Gene Ther 16 : 157 ~ 168
4. [학술지(정기간행물)] - Croyle MA / 1998 / Development of a highly efficient purification process for recombinant adenoviral vectors for oral gene delivery / Pharm Dev Technol 3 : 365 ~ 372
5. [학술지(정기간행물)] - Danthinne X / 2000 / Production of first generation adenovirus vectors: a review / Gene Ther 7 : 1707 ~ 1714
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