지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2009.9
- 수록면
- 213 - 218 (6page)
이용수
초록· 키워드
오류제보하기
1-bromopropane (1-BP) has been used in numerous purposes such as an intermediate in the synthesis of pharmaceuticals, a solvent for fats, waxes, or resins and a substitute for chlorofluorocarbons that destroy the ozone layer. However, the studies related to the modulation of activities of hepatic cytochrome P4S0s (CYPs) are not reported yet. This study was the first study to investigate the potential effect for the activities of hepatic CYPs by the treatment of 1-BP in vivo. When 1-BP was treated to male ICR mice by dose-dependently at the dose levels of 200, 500 and 1,000 ㎎/㎏ of body weight once, the activity of CYP2E1 was selectively increased for 24 h. The inductive potency for the activity of CYP2E1 by 1-BP was equal to induction by acetone a well-known selective CYP2E1 inducer. The present results indicated that 1-BP would affect the metabolism of 1-BP itself and/or other xenobiotics.
목차
ABSTRACT
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
ACKNOWLEDGMENTS
REFERENCES
참고문헌 (26)
참고문헌 신청
1. [학술지(정기간행물)] - Blank JA / 1987 / α-Naphthoflavone antagonism of 2,3,7,8-tetrachlorodibenzo-p-dioxin induced murine ethoxyresorufin Odeethylase activity and immunosuppression / Mol Pharmacol 32 : 168 ~ 172
2. [학술지(정기간행물)] - Boekelheide K / 2004 / NTP-CERHR expert panel report on the reproductive and developmental toxicity of 1-bromopropane / Reprod Toxicol 18 : 157 ~ 188
3. [학술지(정기간행물)] - Chen RM / 1997 / Induction of cytochromes P450 1A, 2B and 2E in hamster tissues by acetone / Arch Toxicol 71 : 489 ~ 495
4. [학술지(정기간행물)] - Djordjevic N / 2008 / Induction of CYP1A2 by heavy coffee consumption in Serbs and Swedes / Eur J Clin Pharmacol 64 : 381 ~ 385
5. [학술지(정기간행물)] - Garner CE / 2007 / CYP2E1-catalyzed oxidation contributes to the sperm toxicity of 1-bromopropane in mice / Biol Reprod 76 : 496 ~ 505
2. [학술지(정기간행물)] - Boekelheide K / 2004 / NTP-CERHR expert panel report on the reproductive and developmental toxicity of 1-bromopropane / Reprod Toxicol 18 : 157 ~ 188
3. [학술지(정기간행물)] - Chen RM / 1997 / Induction of cytochromes P450 1A, 2B and 2E in hamster tissues by acetone / Arch Toxicol 71 : 489 ~ 495
4. [학술지(정기간행물)] - Djordjevic N / 2008 / Induction of CYP1A2 by heavy coffee consumption in Serbs and Swedes / Eur J Clin Pharmacol 64 : 381 ~ 385
5. [학술지(정기간행물)] - Garner CE / 2007 / CYP2E1-catalyzed oxidation contributes to the sperm toxicity of 1-bromopropane in mice / Biol Reprod 76 : 496 ~ 505
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
한약재의 Cytochrome P450 결합관련 안전성에 관한 연구
대한한방내과학회지
2013 .01
-
Effects of CYP1A2$^*$1C and CYP1A2$^*$1F Genotypes on the Activity and Inducibility of CYP1A2 Determined by Urinary Caffeine Metabolite Ratio in Koreans
Molecular & cellular toxicology
2007 .01
-
Effects of Korean traditional herbal formula for common cold on the activities of human CYP450 isozymes
대한한의학회지
2014 .06
-
CYP2E1과 CYP2C19 유전자 다형성이 위암 발생 감수성에 미치는 영향
Annals of Surgical Treatment and Research
2007 .08
-
Expression of CYP2A6, CYP2D6 and CYP4A11 Polymorphisms in COS7 Mammalian Cell Line
Toxicological Research
2011 .03
-
CYP2E15B, CYP2E16, CYP2E17B, CYP2E12, and CYP2E13 Allele Frequencies in Iranian Populations
Asian Pacific journal of cancer prevention : APJCP
2012 .01
-
Hepatotoxic Effect of 1-Bromopropane and Its Conjugation with Glutathione in Male ICR Mice
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
2005 .01
-
Simultaneous determination of seven major human cytochrome P450 activities using LC/MS/MS
대한약학회 학술대회
2002 .01
-
암브록솔과 세티리진의 Cytochrome P450 저해 활성 평가
약학회지
2013 .01
-
RNA Expression of Cytochrome P450 in Mexican Women with Breast Cancer
Asian Pacific journal of cancer prevention : APJCP
2012 .01
-
Modulation of the Inducibility by Intro-1 Binding Proteins (In1BPs) in Human CYP1A2*1C and CYP1A2*1F Genetic Polymorphism
대한임상약리학회 학술대회
2004 .01
-
No Role of Protected Region B of Human Cytochrome P4501A2 Gene (CYP1A2) As an AP-1 Response Element
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
2002 .01
-
한국인 정신분열병 환자의 지연성 운동장애와 $CYP2D6^*4$ 및 $CYP2D6^*10$ 다형성들의 연합에 대한 고찰
생물정신의학
2000 .01
-
약물대사효소 CYP2C19, CYP2D6의 다형성과 사상체질의 관련성 연구
대한한의학회지
2007 .03
-
Xylene에 의한 CYP2B1/2의 유도와 대사에 있어서 toluene의 영향
한국산업보건학회지
2009 .01
-
The selective induction of leelamine on hepatic CYP 2B activity in ICR mice
환경독성보건학회 심포지엄 및 학술대회
2014 .05
-
Preferential Induction of CYP1A1 over CYP1B1 in Human Breast Cancer MCF-7 Cells after Exposure to Berberine
Asian Pacific journal of cancer prevention : APJCP
2014 .01
-
Importance of Cytochrome P450 3A4 Conformation for the Activity Stimulation by Cytochrome b5 : Specific Inhibition of Cytochrome P450 3A4 by Zinc (II) Ion
대한약학회 학술대회
2003 .01
-
Analysis of CYP17, CYP19 and CYP1A1 Gene Polymorphisms in Iranian Women with Breast Cancer
Asian Pacific journal of cancer prevention : APJCP
2016 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-ECN-0101-2009-539-018968868