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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2009.12
- 수록면
- 355 - 360 (6page)
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Phenanthrene (C₁₄H₁?) is a polycyclic aromatic hydrocarbon with three aromatic rings, and it can be produced by incomplete combustion of fossil fuels. Comet assay was used to examine the oxidative DNA damage of lymphocytes by phenanthrene and to measure the suppressive effects of ginseng extract on the DNA damage in this investigation. The in vitro oxidative DNA damage by phenanthrene increased in a dose-dependent manner in the lymphocyte. However, the DNA damage was significantly inhibited by ascorbate. Moreover, pretreatment, cotreatment and posttreatment with ginseng extract enhanced lymphocyte resistance to the phenanthrene?induced DNA damage. Phenanthrene enhanced the generation of intracellular reactive oxygen species, and the elevated reactive oxygen species level was reduced by treatment with ginseng extract.
목차
Abstract
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재료 및 방법
결과 및 고찰
인용문헌
참고문헌 (23)
참고문헌 신청
1. [학술지(정기간행물)] - Tarantini A / 2009 / Relative contribution of DNA strand breaks and DNA adducts to the genotoxicity of benzo[a]pyrene as a pure compound and in complex mixtures / Mutat Res. 671 : 67 ~ 75
2. [학술지(정기간행물)] - Park JH / 2009 / The aryl-hydrocarbon receptor (AhR) facilitates DNA strand breaks and 8-oxo-2'-deoxyguanosine formation by the aldo-keto reductase product benzo[a]pyrene-7,8-dione / J Biol Chem. 284 : 29725 ~ 29734
3. [학술지(정기간행물)] - Pesch B / 2007 / Dose-response modeling of occupational exposure to polycyclic aromatic hydrocarbons with biomarkers of exposure and effect / Cancer Epidemiol Biomarkers Prev. 16 : 1863 ~ 1873
4. [학술지(정기간행물)] - andez-Luqueno F / 2009 / Flocculant in wastewater affects dynamics of inorganic N and accelerates removal of phenanthrene and anthracene in soil / J Environ Manage. 90 : 2813 ~ 2818
5. [학술지(정기간행물)] - Tsai JC / 2009 / Determination of optimal phenanthrene, sulfate and biomass concentrations for anaerobic biodegradation of phenanthrene by sulfatereducing bacteria and elucidation of metabolic pathway / J Hazard Mater. 171 : 1112 ~ 1119
2. [학술지(정기간행물)] - Park JH / 2009 / The aryl-hydrocarbon receptor (AhR) facilitates DNA strand breaks and 8-oxo-2'-deoxyguanosine formation by the aldo-keto reductase product benzo[a]pyrene-7,8-dione / J Biol Chem. 284 : 29725 ~ 29734
3. [학술지(정기간행물)] - Pesch B / 2007 / Dose-response modeling of occupational exposure to polycyclic aromatic hydrocarbons with biomarkers of exposure and effect / Cancer Epidemiol Biomarkers Prev. 16 : 1863 ~ 1873
4. [학술지(정기간행물)] - andez-Luqueno F / 2009 / Flocculant in wastewater affects dynamics of inorganic N and accelerates removal of phenanthrene and anthracene in soil / J Environ Manage. 90 : 2813 ~ 2818
5. [학술지(정기간행물)] - Tsai JC / 2009 / Determination of optimal phenanthrene, sulfate and biomass concentrations for anaerobic biodegradation of phenanthrene by sulfatereducing bacteria and elucidation of metabolic pathway / J Hazard Mater. 171 : 1112 ~ 1119
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