지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.9
- 수록면
- 272 - 282 (11page)
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초록· 키워드
오류제보하기
Ginseng (Panax ginseng Meyer) has been shown to have anti-aging effects in animal and clinical studies. However, the molecular mechanisms by which ginseng exerts these effects remain unknown. Here, the anti-aging effect of Korean red ginseng(KRG) in rat testes was examined by system biology analysis. KRG water extract prepared in feed pellets was administered orally into 12 month old rats for 4 months, and gene expression in testes was determined by microarray analysis. Microarray analysis identified 33 genes that significantly changed. Compared to the 2 month old young rats, 13 genes (Rps9, Cyp11a1, RT1-A2, LOC365778, Sv2b, RGD1565959, RGD1304748, etc.) were up-regulated and 20 genes (RT1-Db1, Cldn5, Svs5, Degs1, Vdac3, Hbb, LOC684355, Svs5, Tmem97, Orai1, Insl3, LOC497959, etc.) were down-regulated by KRG in the older rats. Ingenuity Pathway Analysis of untreated aged rats versus aged rats treated with KRG showed that the affected most was Cyp11a1, responsible for C21-steroid hormone metabolism, and the top molecular and cellular functions are organ morphology and reproductive system development and function. When genes in young rat were compared with those in the aged rat, sperm capacitation related genes were down-regulated in the old rat. However, when genes in the old rat were compared with those in the old rat treated with KRG, KRG treatment up-regulated C21-steroid hormone metabolism. Taken together, Cyp11a1 expression is decreased in the aged rat, however, it is up-regulated by KRG suggesting that KRG seems enhance testes function via Cyp11a1.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
ACKNOWLEDGEMENTS
REFERENCES
참고문헌 (20)
참고문헌 신청
1. [학술지(정기간행물)] - 남기열 / 2005 / 홍삼과 백삼의 비교 고찰 / Journal of Ginseng Research 29 (1) : 1 ~ 18
2. [학술지(정기간행물)] - Yang WM / 2011 / Effects of Panax ginseng on Glial Cell-derived Neurotrophic Factor (GDNF) Expression and Spermatogenesis in Rats / PHYTOTHERAPY RESEARCH 25 (2) : 308 ~ 311
3. [학술지(정기간행물)] - Park WS / 2007 / Korean ginseng induces spermatogenesis in rats through the activation of cAMP-responsive element modulator (CREM) / FERTILITY AND STERILITY 88 (4) : 1000 ~ 1002
4. [학술지(정기간행물)] - Jeong Sook Park / 2006 / The Therapeutic Effect of Tissue Cultured Root of Wild Panax ginseng C.A. Mayer on Spermatogenetic Disorder / Archives of Pharmacal Research 29 (9) : 800 ~ 807
5. [학술지(정기간행물)] - Hwang SY / 2004 / Panax ginseng improves survival and sperm quality in guinea pigs exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin / BJU INTERNATIONAL 94 (0) : 663 ~ 668
2. [학술지(정기간행물)] - Yang WM / 2011 / Effects of Panax ginseng on Glial Cell-derived Neurotrophic Factor (GDNF) Expression and Spermatogenesis in Rats / PHYTOTHERAPY RESEARCH 25 (2) : 308 ~ 311
3. [학술지(정기간행물)] - Park WS / 2007 / Korean ginseng induces spermatogenesis in rats through the activation of cAMP-responsive element modulator (CREM) / FERTILITY AND STERILITY 88 (4) : 1000 ~ 1002
4. [학술지(정기간행물)] - Jeong Sook Park / 2006 / The Therapeutic Effect of Tissue Cultured Root of Wild Panax ginseng C.A. Mayer on Spermatogenetic Disorder / Archives of Pharmacal Research 29 (9) : 800 ~ 807
5. [학술지(정기간행물)] - Hwang SY / 2004 / Panax ginseng improves survival and sperm quality in guinea pigs exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin / BJU INTERNATIONAL 94 (0) : 663 ~ 668
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UCI(KEPA) : I410-ECN-0101-2013-524-000762187