지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2008.12
- 수록면
- 1,228 - 1,234 (7page)
이용수
초록· 키워드
오류제보하기
Having idea to develop more effective anti-diabetic agent from ginseng root, we comprehensively assessed the anti-diabetic activity and mechanisms of ginsam in C57BL/KsJ db/db mice. The db/db mice were divided into 4 groups; diabetic control (DC), ginsam at a dose of 300 or 500 ㎎/㎏ (GS300 or GS500) and metformin at a dose of 300 ㎎/㎏ (MT300). Ginsam was orally administered for 8 weeks. GS500 reduced the blood glucose concentration and significantly decreased an insulin resistance index. In addition, GS500 reduced the plasma non-esterified fatty acid, triglyceride, and increased high density lipoprotein-cholesterol as well as decreased the hepatic cholesterol and triglyceride. More interestingly, ginsam increased the plasma adiponectin level by 17% compared to diabetic control group. Microarray, quantitativepolymerase chain reaction and enzyme activity results showed that gene and protein expressions associated with glycolysis, gluconeogenesis, and fatty acid oxidation were changed to the way of reducing hepatic glucose production, insulin resistance and enhancing fatty acid β-oxidation. Ginsam also increased the phosphorylation of AMP-activated protein kinase and glucose transporter expressions in the liver and skeletal muscle, respectively. These changes in gene expression were considered to be the mechanism by which the ginsam exerted the anti-diabetic and anti-dyslipidemic activities in C57BL/KsJ db/db mice.
목차
Abstract
Introduction
Materials and Methods
Results and Discussion
Acknowledgments
References
참고문헌 (36)
참고문헌 신청
Zimmet P / 2001 / Global and societal implications of the diabetes epidemic / Nature 414:782~787
Friedman JM / 2003 / A war on obesity, not the obese / Science 299:856~858
Cavaghan MK / 2000 / Interactions between insulin resistance and insulin secretion in the development of glucose intolerance / J. Clin. Invest 106:329~333
Moller DE / 2001 / New drug targets for type 2 diabetes and the metabolic syndrome / Nature 414:821~827
Inzucchi SE / 2002 / Oral antihyperglycemic therapy for type 2 diabetes: Scientific review / J. Am. Med. Assoc 287:360~372
Friedman JM / 2003 / A war on obesity, not the obese / Science 299:856~858
Cavaghan MK / 2000 / Interactions between insulin resistance and insulin secretion in the development of glucose intolerance / J. Clin. Invest 106:329~333
Moller DE / 2001 / New drug targets for type 2 diabetes and the metabolic syndrome / Nature 414:821~827
Inzucchi SE / 2002 / Oral antihyperglycemic therapy for type 2 diabetes: Scientific review / J. Am. Med. Assoc 287:360~372
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UCI(KEPA) : I410-ECN-0101-2013-573-000858392