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논문 기본 정보

자료유형
학술저널
저자정보
Young-Hee Pyo (Sungshin Women’s University) Mi-Ja Kwon (Vitamin Bank) In-Ho Kim (Korea Food Research Institute)
저널정보
한국식품과학회 Food Science and Biotechnology Food Science and Biotechnology vol 17. no 2
발행연도
2008.4
수록면
434 - 437 (4page)

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초록· 키워드

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The aim of this study was to investigate whether Monascus-fermented soybean extracts (MFSE) containing natural estrogen-like compounds such as isoflavones and mevinolins has potential effects on human osteoblast-like SaOS2 cells using 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide (MTT) and alkaline phophatase (ALP) assaies. MFSE exerted biphasic dose-dependent effect; stimulating osteoblastic activity at low concentrations and inhibiting SaOS2 cells viability at high concentrations. At 10<sup>?8</sup>-10<sup>?4</sup> mg /mL, MFSE is not only non-cytotoxic but also induced comparatively high ALP activity on SaOS2 cells. ALP activity (%) significantly increased (220.1%, p<0.05) when SaOS2 cells were treated with MFSE at a concentration of 10<sup>?5</sup> mg/mL, whereas slowly increased (185.6%, p<0.05) in unfermented soybean extracts (UFSE) at 10<sup>?3</sup> mg/mL. The potentially greater ALP activity of MFSE compared to the UFSE might partially be caused by its mevinolin, which was derived from the soybean during Monascus-fermentation. Our findings indicate that supplementation of MFSE may accelerate the speed of intracellular ALP synthesis by the bone cells when provided at optimal dosages.

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Abstract
Introduction
Materials and Methods
Results and Discussion
Acknowledgments
References

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