지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2010.6
- 수록면
- 376 - 384 (9page)
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이 논문의 연구 히스토리 (2)
2010
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Purpose: Gastrointestinal stromal tumors (GISTs) possess highly variable clinical behaviors and the study thereof is insufficient. There are no standard guidelines for diagnosis and treatment of GISTs, so it is difficult to predict recurrences and conduct appropriate treatments. Throughout the last 10 years of experiences with GIST patients, we have identified the variables predicting recurrences and classified the risk groups by NIH classification, Fletcher risk stratification and UICC TNM stage.
Methods: From January 1998 to December 2007, 88 patients with pathologic confirm and surgical resection were diagnosed with GISTs. GISTs were diagnosed when the tumor had characteristic histologic features and confirmed positive by KIT, CD34, or PDGFRA.
Results: The size, mitotic index, existence of symptoms, and origins of tumor correlate statistically with recurrence (0.002, ＜0.001, 0.027, 0.011). The NIH classification, Fletcher risk stratification and UICC TNM stage are correlated with recurrence (0.001, ＜0.001, ＜0.001) and 5 year disease free survival, statistically (0.009, ＜0.001, ＜0.001). Fifteen patients experienced recurrences. 14 patients were treated with imatinib, and 6 of them showed a response to the treatment. All 4 patients who had R1 resection did not survived due to the progression of the disease.
Conclusion: The patients with large, high mitotic index, symptomatic, or extra-gastric tumor require strict surveillance. Also, patients with low risk must be under surveillance due to the possibility of recurrence. It is important to perform R0, en bloc resection. Although the imatinib is the treatment of choice with recurred or metastatic GISTs, the disease is likely to develop resistance, further studies on newly targeted therapy is in need.
Methods: From January 1998 to December 2007, 88 patients with pathologic confirm and surgical resection were diagnosed with GISTs. GISTs were diagnosed when the tumor had characteristic histologic features and confirmed positive by KIT, CD34, or PDGFRA.
Results: The size, mitotic index, existence of symptoms, and origins of tumor correlate statistically with recurrence (0.002, ＜0.001, 0.027, 0.011). The NIH classification, Fletcher risk stratification and UICC TNM stage are correlated with recurrence (0.001, ＜0.001, ＜0.001) and 5 year disease free survival, statistically (0.009, ＜0.001, ＜0.001). Fifteen patients experienced recurrences. 14 patients were treated with imatinib, and 6 of them showed a response to the treatment. All 4 patients who had R1 resection did not survived due to the progression of the disease.
Conclusion: The patients with large, high mitotic index, symptomatic, or extra-gastric tumor require strict surveillance. Also, patients with low risk must be under surveillance due to the possibility of recurrence. It is important to perform R0, en bloc resection. Although the imatinib is the treatment of choice with recurred or metastatic GISTs, the disease is likely to develop resistance, further studies on newly targeted therapy is in need.
목차
서론
방법
결과
고찰
결론
REFERENCES
참고문헌 (24)
참고문헌 신청
1. [학술지(정기간행물)] - Fletcher CD / 2002 / Diagnosis of gastrointestinal stromal tumors: A consensus approach / Hum Pathol 33 : 459 ~ 465
2. [학술지(정기간행물)] - Kindblom LG / 1998 / Gastrointestinal pacemaker cell tumor (GIPACT): gastrointestinal stromal tumors show phenotypic characteristics of the interstitial cells of Cajal / Am J Pathol 152 : 1259 ~ 1269
3. [학술지(정기간행물)] - Hirota S / 1998 / Gain-of-function mutations of c-kit in human gastrointestinal stromal tumors / Science 279 : 577 ~ 580
4. [학술지(정기간행물)] - Heinrich MC / 2003 / PDGFRA activating mutations in gastrointestinal stromal tumors / Science 299 : 708 ~ 710
5. [학술지(정기간행물)] - Corless CL / 2002 / KIT mutations are common in incidental gastrointestinal stromal tumors one centimeter or less in size / Am J Pathol 160 : 1567 ~ 1572
2. [학술지(정기간행물)] - Kindblom LG / 1998 / Gastrointestinal pacemaker cell tumor (GIPACT): gastrointestinal stromal tumors show phenotypic characteristics of the interstitial cells of Cajal / Am J Pathol 152 : 1259 ~ 1269
3. [학술지(정기간행물)] - Hirota S / 1998 / Gain-of-function mutations of c-kit in human gastrointestinal stromal tumors / Science 279 : 577 ~ 580
4. [학술지(정기간행물)] - Heinrich MC / 2003 / PDGFRA activating mutations in gastrointestinal stromal tumors / Science 299 : 708 ~ 710
5. [학술지(정기간행물)] - Corless CL / 2002 / KIT mutations are common in incidental gastrointestinal stromal tumors one centimeter or less in size / Am J Pathol 160 : 1567 ~ 1572
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