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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한병리학회 Journal of Pathology and Translational Medicine Journal of Pathology and Translational Medicine 제40권 제2호
- 발행연도
- 2006.1
- 수록면
- 137 - 141 (5page)
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Gastrointestinal stromal tumor (GIST) is the most common non-epithelial neoplasm arising in
the gastrointestinal tract, but this tumor is rarely seen in association with type 1 neurofibromatosis
(NF-1). We report here on two cases of multiple GISTs of the small intestine that occurred in
NF-1 patients. We also analyzed the mutations of c-kit exons 9, 11, 13 and 17 and the plateletderived
growth factor receptor-alpha (PDGFRA) exons 12 and 18 in two GIST patients. Histologically,
the NF-1-associated GISTs were similar to those of non-the NF-1 GISTs, but they
characteristically revealed hyperplastic interstitial cells of Cajal around the GISTs. Immunohistochemically,
these tumors showed strong co-expressions of CD117 and CD34. The molecular
genetic analysis of the GISTs showed that all of the c-kit and PDGFRA exons that were
analyzed in the GISTs of the two patients were the wild-type, suggesting a limited role for the
c-kit and PDGFRA mutations in the tumorigenesis of NF-1-associated GISTs.
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참고문헌 (13)
참고문헌 신청
Boldorini R / 2001 / Multiple small intestinalstromal tumours in a patient with previously unrecognised neurofibromatosistype 1:immunohistochemical and ultrastructural evalua
Carrillo R / 1997 / Prognostic significanceof DNA ploidy and proliferative index(MIB-1 index)ingastrointestinal stromal tumors 28 : 160 ~ 165
Heinrich MC / 2003 / Kinase mutations andimatinib response in patients with metastatic gastrointestinal stromaltumor 21 : 4342 ~ 4349
Hirota S / 1998 / Gain-of-function mutationsof c-kit in human gastrointestinal stromal tumors 279 : 577 ~ 580
Hirota S / 2003 / Gain-of-function mutations ofplatelet-derived growth factor receptor alpha gene in gastrointestinalstromal tumors 125 : 660 ~ 667
Carrillo R / 1997 / Prognostic significanceof DNA ploidy and proliferative index(MIB-1 index)ingastrointestinal stromal tumors 28 : 160 ~ 165
Heinrich MC / 2003 / Kinase mutations andimatinib response in patients with metastatic gastrointestinal stromaltumor 21 : 4342 ~ 4349
Hirota S / 1998 / Gain-of-function mutationsof c-kit in human gastrointestinal stromal tumors 279 : 577 ~ 580
Hirota S / 2003 / Gain-of-function mutations ofplatelet-derived growth factor receptor alpha gene in gastrointestinalstromal tumors 125 : 660 ~ 667
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직장에 발생한 Gastrointestinal Stromal Tumor(GIST)의 임상적 고찰
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재발한 위장관 간질성 종양(GISTs) 환자들의 임상양상 분석
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