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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2008.7
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- 41 - 46 (6page)
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Purpose: The purpose of this study is to comprehend the prognosis and risk factors for the early recurrence after resection for hepatocellular carcinoma (HCC).
Methods: Between 1997 and 2005, 237 patients underwent curative resection for HCC at Kyungpook National University Hospital. The patients were followed up regularly to detect any recurrences of HCC by performing imaging studies and AFP. Early recurrence was defined as recurrence that occurred within one year after resection. The patients were divided into the early recurrence group and the others, which included both patients without recurrence and with recurrence that occurred later than 1 year after resection. The clinicopathologic factors of both group were compared to identify the prognosis and the risk factors by performing univariate and multivariate analyses.
Results: Seventy three patients (30.8%, 73/238) had early recurrence after resection and 164 patients (69.2%, 164/238) didn`t have recurrence in the first year. The survival rate was significantly better in the without early recurrence group than that in the early recurrence group (96.3% vs 60.3% and 85.1% vs 23.4%, 62.8% vs 7.3% 1, 3, 5 years). The risk factors for early recurrence in the HCC patients were a tumor size greater than 5 ㎝ (P=0.011; odds ratio=2.304) and vascular invasion (P=＜0.001; odds ratio=6.342).
Conclusion: Since a large tumor size and vascular invasion are the risk factors for early recurrence, the patients who have these risk factors should be followed up with caution and possible postoperative adjuvant therapeutic trials should be considered.
Methods: Between 1997 and 2005, 237 patients underwent curative resection for HCC at Kyungpook National University Hospital. The patients were followed up regularly to detect any recurrences of HCC by performing imaging studies and AFP. Early recurrence was defined as recurrence that occurred within one year after resection. The patients were divided into the early recurrence group and the others, which included both patients without recurrence and with recurrence that occurred later than 1 year after resection. The clinicopathologic factors of both group were compared to identify the prognosis and the risk factors by performing univariate and multivariate analyses.
Results: Seventy three patients (30.8%, 73/238) had early recurrence after resection and 164 patients (69.2%, 164/238) didn`t have recurrence in the first year. The survival rate was significantly better in the without early recurrence group than that in the early recurrence group (96.3% vs 60.3% and 85.1% vs 23.4%, 62.8% vs 7.3% 1, 3, 5 years). The risk factors for early recurrence in the HCC patients were a tumor size greater than 5 ㎝ (P=0.011; odds ratio=2.304) and vascular invasion (P=＜0.001; odds ratio=6.342).
Conclusion: Since a large tumor size and vascular invasion are the risk factors for early recurrence, the patients who have these risk factors should be followed up with caution and possible postoperative adjuvant therapeutic trials should be considered.
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REFERENCES
참고문헌 (21)
참고문헌 신청
1. [기타자료] - Korea central cancer ministry of health and welfare / / 2002 Annual report of the Korea central cancer registry (Based on registered data from 139 hospitals)
2. [학술지(정기간행물)] - Blum HE / 2005 / Hepatocellular carcinoma: Therapy and Prevention / World J Gastroenterol 11 : 7391 ~ 7400
3. [학술지(정기간행물)] - Llovet JM / 2005 / Updated treatment approach to hepatocellular carcinoma / J Gastroenterol 40 : 225 ~ 235
4. [학술지(정기간행물)] - Akriviadis EA / 1998 / Hepatocellular carcinoma / Br J Surg 85 : 1319 ~ 1331
5. [학술지(정기간행물)] - Otto G / 1998 / Survival and recurrence after liver transplantation versus liver resection for hepatocellular carcinoma: a retrospective analysis / Ann Surg 227 : 424 ~ 432
2. [학술지(정기간행물)] - Blum HE / 2005 / Hepatocellular carcinoma: Therapy and Prevention / World J Gastroenterol 11 : 7391 ~ 7400
3. [학술지(정기간행물)] - Llovet JM / 2005 / Updated treatment approach to hepatocellular carcinoma / J Gastroenterol 40 : 225 ~ 235
4. [학술지(정기간행물)] - Akriviadis EA / 1998 / Hepatocellular carcinoma / Br J Surg 85 : 1319 ~ 1331
5. [학술지(정기간행물)] - Otto G / 1998 / Survival and recurrence after liver transplantation versus liver resection for hepatocellular carcinoma: a retrospective analysis / Ann Surg 227 : 424 ~ 432
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UCI(KEPA) : I410-ECN-0101-2013-514-002691132