지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2009.12
- 수록면
- 235 - 241 (7page)
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Purpose: We wanted to evaluate the influence of preoperative non-surgical treatment and its duration for hepatocellular carcinoma (HCC) patients who underwent liver transplantation (LT).
Methods: We analyzed 75 patients with HCC who underwent living donor liver transplantation from January 1999 to December 2005. The median follow-up was 40.2 months. The patients were divided into the not treated group (26 patients) and non-surgically treated group (49 patients). We compared the overall survival (OS) and disease-free survival (DFS) rates of the 24 not treated patients with that of the 33 treated patients within the Milan criteria. The treated group was divided to 39 short-term (＜3 years) treated patients and 10 long-term (≥3 years)treated patients by the preoperative treatment duration. The OS and DFS rates were analyzed.
Results: For 57 patients within the Milan criteria, the 1-, 3- and 5-year OS rates and the 1-, 3- and 5-year DFS rates were 80.0%, 68.5%, 64.8%, 82.0%, 77.2% and 75.1%, respectively. There were no different characteristic between the not treated group and the treated group, except for the mean age and the Child-Turcotte-Pugh score. Compared to the treated group, the OS and DFS rates were slightly better in the not treated group (p=0.053). There were more patients who underwent transcatheter arterial chemoembolization only in the short-term treated group and there were more patients who had microvascular invasion in the long-term treated group. The OS and DFS rates showed no significant difference between the two groups.
Conclusion: It is possible that LT is a first treatment for HCC patients. If the patients’ response to preoperative treatment was good, then their prognosis may be same regardless of the treatment duration.
Methods: We analyzed 75 patients with HCC who underwent living donor liver transplantation from January 1999 to December 2005. The median follow-up was 40.2 months. The patients were divided into the not treated group (26 patients) and non-surgically treated group (49 patients). We compared the overall survival (OS) and disease-free survival (DFS) rates of the 24 not treated patients with that of the 33 treated patients within the Milan criteria. The treated group was divided to 39 short-term (＜3 years) treated patients and 10 long-term (≥3 years)treated patients by the preoperative treatment duration. The OS and DFS rates were analyzed.
Results: For 57 patients within the Milan criteria, the 1-, 3- and 5-year OS rates and the 1-, 3- and 5-year DFS rates were 80.0%, 68.5%, 64.8%, 82.0%, 77.2% and 75.1%, respectively. There were no different characteristic between the not treated group and the treated group, except for the mean age and the Child-Turcotte-Pugh score. Compared to the treated group, the OS and DFS rates were slightly better in the not treated group (p=0.053). There were more patients who underwent transcatheter arterial chemoembolization only in the short-term treated group and there were more patients who had microvascular invasion in the long-term treated group. The OS and DFS rates showed no significant difference between the two groups.
Conclusion: It is possible that LT is a first treatment for HCC patients. If the patients’ response to preoperative treatment was good, then their prognosis may be same regardless of the treatment duration.
목차
서론
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결과
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참고문헌
참고문헌 (22)
참고문헌 신청
1. [학술지(정기간행물)] - de Villa V / 2007 / Liver transplantation for hepatocellular carcinoma in Asia / Oncologist 12 : 1321 ~ 1331
2. [학술지(정기간행물)] - Botha JF / 2006 / Liver transplantation for hepatocellular carcinoma: an update / J Natl Compr Canc Netw 8 : 762 ~ 767
3. [학술지(정기간행물)] - Decaens T / 2005 / Impact of pretransplantation transarterial chemoembolization on survival and recurrence after liver transplantation for hepatocellular carcinoma / Liver Transpl 11 : 767 ~ 775
4. [학술지(정기간행물)] - Belghiti J / 2008 / Treatment before liver transplantation for HCC / Surg Oncol 15 : 993 ~ 1000
5. [학술지(정기간행물)] - Schwartz M / 2007 / Treatment of HCC in patients awaiting liver transplantation / Am J Transplant 7 : 1875 ~ 1881
2. [학술지(정기간행물)] - Botha JF / 2006 / Liver transplantation for hepatocellular carcinoma: an update / J Natl Compr Canc Netw 8 : 762 ~ 767
3. [학술지(정기간행물)] - Decaens T / 2005 / Impact of pretransplantation transarterial chemoembolization on survival and recurrence after liver transplantation for hepatocellular carcinoma / Liver Transpl 11 : 767 ~ 775
4. [학술지(정기간행물)] - Belghiti J / 2008 / Treatment before liver transplantation for HCC / Surg Oncol 15 : 993 ~ 1000
5. [학술지(정기간행물)] - Schwartz M / 2007 / Treatment of HCC in patients awaiting liver transplantation / Am J Transplant 7 : 1875 ~ 1881
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UCI(KEPA) : I410-ECN-0101-2014-514-001253394