지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2010.12
- 수록면
- 291 - 295 (5page)
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초록· 키워드
오류제보하기
The onset, severity, and ultimate outcome of malaria infection are influenced by parasite-expressed virulence factors and individual host responses to these determinants. In both humans and mice, liver injury is involved after parasite entry, which persists until the erythrocyte stage after infection with the fatal strain Plasmodium falciparum (Pf). Hepatocyte growth factor (HGF) has strong anti-apoptotic effects in various kinds of cells, and also has diverse metabolic functions. In this work, Pf-subtilisin-like protease 2 (Pf-Sub2) 5′untranslated region (UTR) was analyzed and its transcriptional activity was estimated by luciferase expression. Fourteen TATA boxes were observed but only one Oct-1 and c-Myb were done. In addition, host HGF interaction with Pf-Sub2 was evaluated by co-transfection of HGF- and Pf-Sub2-cloned vector. Interestingly, -1,422/+12 UTR exhibited the strongest luciferase activity but -329 to +12 UTR did not exhibit luciferase activity. Moreover, as compared with the control of unexpressed HGF, the HGF protein suppressed luciferase expression driven by the 5′untranslated region of the Pf-Sub2 promoter. Taken together, it is suggested that HGF controls and interacts with the promoter region of the Pf-Sub2 gene.
목차
Abstract
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (33)
참고문헌 신청
Kooij TW / 2006 / Plasmodium post-genomics: better the bug you know? / Nat Rev Microbiol 4:344~357
Fortin A / 2002 / Complex genetic control of susceptibility to malaria in mice / Genes Immun 3:177~186
Griffith JW / 2007 / Toll-like receptor modulation of murine cerebral malaria is dependent on the genetic background of the host / J Infect Dis 196:1553~1564
Millington OR / 2007 / Malaria impairs T cell clustering and immune priming despite normal signal 1 from dendritic cells / PLoS Pathog 3:1380~1387
Min-Oo G / 2007 / Complex genetic control of susceptibility to malaria: positional cloning of the Char 9 locus / J Exp Med 204:511~524
Fortin A / 2002 / Complex genetic control of susceptibility to malaria in mice / Genes Immun 3:177~186
Griffith JW / 2007 / Toll-like receptor modulation of murine cerebral malaria is dependent on the genetic background of the host / J Infect Dis 196:1553~1564
Millington OR / 2007 / Malaria impairs T cell clustering and immune priming despite normal signal 1 from dendritic cells / PLoS Pathog 3:1380~1387
Min-Oo G / 2007 / Complex genetic control of susceptibility to malaria: positional cloning of the Char 9 locus / J Exp Med 204:511~524
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UCI(KEPA) : I410-ECN-0101-2014-510-002511893