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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.3
- 수록면
- 35 - 43 (9page)
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Loperamide has long been known as an opioid-receptor agonist useful as a drug for treatment of diarrhea resulting from gastroenteritis or inflammatory bowel disease as well as to induce constipation. To determine and characterize putative biomarkers that can predict constipation induced by loperamide treatment, alteration of endogenous metabolites was measured in the serum of Sprague Dawley (SD) rats treated with loperamide for 3 days using ¹H nuclear magnetic resonance (¹H NMR) spectral data. The amounts and weights of stool and urine excretion were significantly lower in the loperamide-treated group than the Notreated group, while the thickness of the villus, crypt layer, and muscle layer was decreased in the transverse colon of the same group. The concentrations of aspartate aminotransferase (AST), lactate dehydrogenase (LDH) and creatinine (Cr) were also slightly changed in the loperamide-treated group, although most of the serum components were maintained at a constant level. Furthermore, pattern recognition of endogenous metabolites showed completely separate clustering of the serum analysis parameters between the Notreated group and loperamide-treated group. Among 35 endogenous metabolites, four amino acids (alanine, glutamate, glutamine and glycine) and six endogenous metabolites (acetate, glucose, glycerol, lactate, succinate and taurine) were dramatically decreased in loperamide-treated SD rats. These results provide the first data pertaining to metabolic changes in SD rats with loperamide-induced constipation. Additionally, these findings correlate the changes in 10 metabolites with constipation.
목차
Materials and Methods
Results
Discussion
References
참고문헌 (28)
참고문헌 신청
1. [학술지(정기간행물)] - Stokbroekx RA. / 1973 / Synthetic antidiarrheal agents. 2, 2-Diphenyl-4-(4'-aryl-4'-hydroxypiperidino)butyramides / J Med Chem 16 (7) : 782 ~ 786
2. [학술지(정기간행물)] - Hanauer SB. / 2008 / The role of loperamide in gastrointestinal disorders / Rev Gastroenterol Disord 8 (1) : 15 ~ 20
3. [학술지(정기간행물)] - Vandenbossche J. / 2010 / Loperamide and P-glycoprotein inhibition : assessment of the clinical relevance / J Pharm Pharmacol 62 (4) : 401 ~ 412
4. [단행본] - Katzung BG. / 2004 / Basic and Clinical Pharmacology, 9th ed / McGrawHill Companies Inc : 321 ~ 370
5. [학술지(정기간행물)] - Wintola OA. / 2010 / The effect of Aloe ferox Mill. in the treatment of loperamide-induced constipation in Wistar rats / BMC Gastroenterol 10 : 95 ~
2. [학술지(정기간행물)] - Hanauer SB. / 2008 / The role of loperamide in gastrointestinal disorders / Rev Gastroenterol Disord 8 (1) : 15 ~ 20
3. [학술지(정기간행물)] - Vandenbossche J. / 2010 / Loperamide and P-glycoprotein inhibition : assessment of the clinical relevance / J Pharm Pharmacol 62 (4) : 401 ~ 412
4. [단행본] - Katzung BG. / 2004 / Basic and Clinical Pharmacology, 9th ed / McGrawHill Companies Inc : 321 ~ 370
5. [학술지(정기간행물)] - Wintola OA. / 2010 / The effect of Aloe ferox Mill. in the treatment of loperamide-induced constipation in Wistar rats / BMC Gastroenterol 10 : 95 ~
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UCI(KEPA) : I410-ECN-0101-2015-500-001364452