지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Background: Herbal formulas are generally served as a type of decoction. However, there is no scientific evidence for determining preservation and circulation period of herbal medicine decoctions. Thus, we investigated anti-inflammatory and anti-oxidative effects of the Gwakhyangjeonggi-san decoction according to its preservation period.
Methods: Gwakhyangjeonggi-san decoction was stored for 0, 1, 2 or 3 months at room temperature. To evaluate anti-inflammatory effects, enzyme-linked immunosorbent assays (ELISAs) for tumor necrosis factor-alpha (TNF-α) and interleukin-6 (IL-6), and nitric oxide (NO) assay were conducted using the culture supernatant from RAW 264.7 cells stimulated with lipopolysaccharide (LPS). The antioxidant activities were studied by measuring free radical scavenging activities on ABTS and DPPH.
Results: Gwakhyangjeonggi-san decoction maintained the inhibitory effects on TNF-α, IL-6 and NO productions after up to 2 months of storage in LPS-treated RAW 264.7 cells. No inflammatory response was observed in 3 months of storage. In addition, the scavenging activities on ABTS and DPPH of Gwakhyangjeonggi-san decoction were reduced time-dependently and showed less than 50% inhibition after 3 months of storage.
Conclusions: Our results suggest that preservation period of Gwakhyangjeonggi-san decoction is recommended within 2 months after storage.
Methods: Gwakhyangjeonggi-san decoction was stored for 0, 1, 2 or 3 months at room temperature. To evaluate anti-inflammatory effects, enzyme-linked immunosorbent assays (ELISAs) for tumor necrosis factor-alpha (TNF-α) and interleukin-6 (IL-6), and nitric oxide (NO) assay were conducted using the culture supernatant from RAW 264.7 cells stimulated with lipopolysaccharide (LPS). The antioxidant activities were studied by measuring free radical scavenging activities on ABTS and DPPH.
Results: Gwakhyangjeonggi-san decoction maintained the inhibitory effects on TNF-α, IL-6 and NO productions after up to 2 months of storage in LPS-treated RAW 264.7 cells. No inflammatory response was observed in 3 months of storage. In addition, the scavenging activities on ABTS and DPPH of Gwakhyangjeonggi-san decoction were reduced time-dependently and showed less than 50% inhibition after 3 months of storage.
Conclusions: Our results suggest that preservation period of Gwakhyangjeonggi-san decoction is recommended within 2 months after storage.
목차
서론
재료 및 방법
결과
고찰
결론
참고문헌
참고문헌 (22)
참고문헌 신청
1. [학술지(정기간행물)] - Adessi C / 2002 / Converting a peptide into adrug: strategies to improve stability and bioavailability / Curr Med Chem 9 (9) : 963 ~ 978
2. [단행본] - 한의과대학 방제학교수 / 2003 / 방제학 / Yeongnimsa : 488 ~ 490
3. [학술지(정기간행물)] - Yu C / 2002 / Explore of immune mechanism of HUOXIANG ZHENGQI ORAL LIQUOR restrain degranulation of mast cell / Chin Traditional Patent Med 2 : 120 ~ 121
4. [학술지(정기간행물)] - Yu C / 2003 / Experimental researches on inhibitory effect of Huoxiang Zhengqi Liquid (藿香正气水) on histamine release / Chin J Integrative Med 9 (4) : 276 ~ 280
5. [학술지(정기간행물)] - Sun JK / 2003 / Effects of GwakHyangJungGiSan on the arterial contraction in rabbit / J Korean Oriental Intern 24 (2) : 260 ~ 268
2. [단행본] - 한의과대학 방제학교수 / 2003 / 방제학 / Yeongnimsa : 488 ~ 490
3. [학술지(정기간행물)] - Yu C / 2002 / Explore of immune mechanism of HUOXIANG ZHENGQI ORAL LIQUOR restrain degranulation of mast cell / Chin Traditional Patent Med 2 : 120 ~ 121
4. [학술지(정기간행물)] - Yu C / 2003 / Experimental researches on inhibitory effect of Huoxiang Zhengqi Liquid (藿香正气水) on histamine release / Chin J Integrative Med 9 (4) : 276 ~ 280
5. [학술지(정기간행물)] - Sun JK / 2003 / Effects of GwakHyangJungGiSan on the arterial contraction in rabbit / J Korean Oriental Intern 24 (2) : 260 ~ 268
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UCI(KEPA) : I410-ECN-0101-2015-510-002656144