High Genetic Variability of Schistosoma haematobium in Mali and Nigeria

Charles Ezeh; Mingbo Yin; Hongyan Li; Ting Zhang; Bin Xu; Moussa Sacko; Zheng Feng; Wei Hu

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자료유형: 학술저널

저자정보: Charles Ezeh (Chinese Center for Disease Control and Prevention) Mingbo Yin (Fudan University) Hongyan Li (Fudan University) Ting Zhang (Chinese Center for Disease Control and Prevention) Bin Xu (Chinese Center for Disease Control and Prevention) Moussa Sacko (Institut National de Recherche en Sante Publique) Zheng Feng (Chinese Center for Disease Control and Prevention) Wei Hu (Chinese Center for Disease Control and Prevention)

저널정보: 대한기생충학열대의학회 Parasites, Hosts and Diseases The Korean Journal of Parasitology Vol.53 No.1

발행연도: 2015.2

수록면: 129 - 134 (6page)

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Schistosoma haematobium is one of the most prevalent parasitic flatworms, infecting over 112 million people in Africa. However, little is known about the genetic diversity of natural S. haematobium populations from the human host because of the inaccessible location of adult worms in the host. We used 4 microsatellite loci to genotype individually pooled S. haematobium eggs directly from each patient sampled at 4 endemic locations in Africa. We found that the average allele number of individuals from Mali was significantly higher than that from Nigeria. In addition, no significant difference in allelic composition was detected among the populations within Nigeria; however, the allelic composition was significantly different between Mali and Nigeria populations. This study demonstrated a high level of genetic variability of S. haematobium in the populations from Mali and Nigeria, the 2 major African endemic countries, suggesting that geographical population differentiation may occur in the regions.

#Schistosoma haematobium #allelic diversity #allelic composition #microsatellite #Mali #Nigeria

참고문헌 (23)

참고문헌 신청

Steinmann P / 2006 / Schistosomiasis and water resources development: systematic review, meta-analysis, and estimates of people at risk / Lancet Infect Dis 6:411~425

van der Werf MJ / 2003 / Quantification of clinical morbidity associated with schistosome infection in sub-Saharan Africa / Acta Trop 86:125~139

Brouwer KC / 2003 / Urinary tract pathology attributed to Schistosoma haematobium: does parasite genetics play a role? / Am J Trop Med Hyg 68:456~462

Gower CM / 2011 / Population genetics of Schistosoma haematobium: development of novel microsatellite markers and their application to schistosomiasis control in Mali / Parasitology 138:978~994

Wright CA / 1983 / Enzyme analysis of Schistosoma haematobium / Bull WHO 61:307

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