Pathogenicity of Five Strains of Toxoplasma gondii from Different Animals to Chickens

Shuai Wang; Guang-Wei Zhao; Wang Wang; Zhen-Chao Zhang; Bo Shen; I. A. Hassan; Qing Xie; Ruo-Feng Yan; Xiao-Kai Song; Li-Xin Xu; Xiang-Rui Li

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저자정보: Shuai Wang (Nanjing Agricultural University) Guang-Wei Zhao (Nanjing Agricultural University) Wang Wang (Nanjing Agricultural University) Zhen-Chao Zhang (Nanjing Agricultural University) Bo Shen (Nanjing Agricultural University) I. A. Hassan (Nanjing Agricultural University) Qing Xie (Nanjing Agricultural University) Ruo-Feng Yan (Nanjing Agricultural University) Xiao-Kai Song (Nanjing Agricultural University) Li-Xin Xu (Nanjing Agricultural University) Xiang-Rui Li (Nanjing Agricultural University)

저널정보: 대한기생충학열대의학회 Parasites, Hosts and Diseases The Korean Journal of Parasitology Vol.53 No.2

발행연도: 2015.4

수록면: 155 - 162 (8page)

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Toxoplasma gondii is a protozoan parasite with a broad range of intermediate hosts. Chickens as important food-producing animals can also serve as intermediate hosts. To date, experimental studies on the pathogenicity of T. gondii in broiler chickens were rarely reported. The objective of the present study was to compare the pathogenicity of 5 different T. gondii strains (RH, CN, JS, CAT2, and CAT3) from various host species origin in 10-day-old chickens. Each group of chickens was infected intraperitoneally with 5×108, 1×108, 1×107, and 1×106 tachyzoites of the 5 strains, respectively. The negative control group was mockly inoculated with PBS alone. After infection, clinical symptoms and rectal temperatures of all the chickens were checked daily. Dead chickens during acute phage of the infection were checked for T. gondii tachyzoites by microscope, while living cases were checked for T. gondii infection at day 53 post-inoculation (PI) by PCR method. Histopathological sections were used to observe the pathological changes in the dead chickens and the living animals at day 53 PI. No significant differences were found in survival periods, histopathological findings, and clinical symptoms among the chickens infected with the RH, CN, CAT2, and CAT3 strains. Histopathological findings and clinical symptoms of the JS (chicken origin) group were similar to the others. However, average survival times of infected chickens of the JS group inoculated with 5×108 and 1×108 tachyzoites were 30.0 and 188.4 hr, respectively, significantly shorter than those of the other 4 mammalian isolates. Chickens exposed to 108 of T. gondii tachyzoites and higher showed acute signs of toxoplasmosis, and the lesions were relatively more severe than those exposed to lower doses. The results indicated that the pathogenicity of JS strain was comparatively stronger to the chicken, and the pathogenicity was dose-dependent.

#Toxoplasma gondii #chicken #pathogenicity

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Leila Danehchin, Gholamreza Razmi, Abolghasem Naghibi. Isolation and Genotyping of Toxoplasma gondii Strains in Ovine Aborted Fetuses in Khorasan Razavi Province, Iran. Parasites, Hosts and Diseases. 2016

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