It is undeniable that the study results discussing the relation between Underwood and House of Universal Helpfulness(Che-Jung-Won/濟衆院, Kwang-Hye-Weon/廣蕙院) were insufficient due to the limited understanding attendant on the field of medical institutions or medical educational institutions, in spite of the fact that House of Universal Helpfulness was the first Protestant missionary institution. In other words, it is evident that the studies dealing with Allen, who was the founder, Heron, who was one of the active persons, and Avison, who unconditionally contributed to develop House of Universal Helpfulness to ‘Severance Community’ form the majority of the studies related to the community of House of Universal Helpfulness. On the other hand, in the approach to Underwood himself, it is obvious that the we can hardly find some distinct study results on the aspect of the relation with House of Universal Helpfulness, while the studies on the aspect of the missionary work including the establishment of Sae-Mun-An Church, the bible translation and tract mission, the educational work, especially the foundation of ‘Kyeong-Shin School’ and ‘Yon-Hee University’ have been frequently proceeded. Merely, the General relativity is somewhat mentioned partly or superficially in the studies related to House of Universal Helpfulness and the studies focusing on Underwood as a mail theme. However, it is clear that the missionary institution that Underwood, the first earnest Protestant missionary, came to Korea and engaged in the early work is House of Universal Helpfulness, and so is that House of Universal Helpfulness was influenced by Underwood in its development, turning process, missionary index and direction setting. In this sense, reexamining the related matters the community of House of Universal Helpfulness and Underwood accompanies with a subject of the early church history and missionary history in Korea, and extends a certain horizon in the study of Underwood as an individual. Especially, it is undoubtful that the founder Underwood, generally speaking, is stated only as a founder of ‘Yon-Hee Community’, when supposing, at the present time, the subject of the foundation history of Yonsei University as two axes, ‘Yon-Hee Community’ and ‘Severance Community’. Therefore, the study of the relation between Underwood and House of Universal Helpfulness is in close connection with the study purpose that can demonstrate the efficacy in the realm of the related history between Yonsei University and the founder. Underwood worked as a pharmacist, a medical assistant, and a professor to teach physics, chemistry, fundamental physiology in the medical education course of House of Universal Helpfulness. This work contributed to systematize the early period of House of Universal Helpfulness, as well as established a bridgehead of the missionary work there for Underwood, who had just came to Korea as a reclamation missionary. Especially, the notable fact is that Underwood`s ordinary belief strongly effected the process to set the theological and missionary course of House of Universal Helpfulness, which was founded mainly under Allen`s mission theology and work course, as well as that of Presbyterian medical mission, which was proceeded on the basis of House of Universal Helpfulness. The leadership of Underwood in ‘Presbyterian Council’ at that time, and the different opinions between Allen and understood about mission goal which came up to the surface at House of Universal Helpfulness, this policy is underwood to have been identical with Underwood`s position. Underwood took an active hand and played the positive role in the following process; the laying of the cornerstone on Thanksgiving Day, Nov. 27. 1902, the consecration ceremony on Sep. 23. 1904, and the construction and enlargement of renewed House of Universal Helpfulness, which was officially opened on Nov. 16 of the same year as the first general hospital in Korea with the sc