지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한외과학회 Annals of Surgical Treatment and Research Annals of Surgical Treatment and Research Vol.88 No.5
- 발행연도
- 2015.4
- 수록면
- 241 - 245 (5page)
이용수
초록· 키워드
오류제보하기
Purpose: The efficiency of ischemic postconditioning (IPC) was evaluated in a rat model of ischemic liver. Concentration of survivin of liver tissue correlated with the degree of antiapoptosis, so survivin was estimated to evaluate the efficiency of IPC on ischemic reperfusion (IR) injury.
Methods: Twenty-four healthy rats were divided to three groups (SHAM, IR, and IPC). Rats in the SHAM group displayed no change during 3 hours. Rats in the IR group were ischemic within 1 hour of clamping the left hepatic artery and left portal vein. Reperfusion for 2 hours was then done. IPC group, intermittent 2, 3, 5, and 7 minutes of reperfusion followed by 1 hour of warm ischemia. Two-minute reocclusion was done after each reperfusion. Rat sera were analyzed for AST and ALT, and Western blot analysis of rat liver tissue of rats evaluated malondialdehyde (MDA) and survivin.
Results: MDA in the liver tissue of rats in the IR and IPC group were significantly high than in the liver tissue of the SHAM group (P = 0.003 and P = 0.008, respectively). Survivin was higher in the IPC group than in the SHAM and IR groups (P = 0.021 and P = 0.024, respectively).
Conclusion: IPC could not prevent lipid oxidation in liver cell mitochondria, but did aid in the regeneration of ischemic injured liver cells. The results indicate that IPC can suppress the apoptosis of liver cells and reduce reperfusion injury of liver tissue.
Methods: Twenty-four healthy rats were divided to three groups (SHAM, IR, and IPC). Rats in the SHAM group displayed no change during 3 hours. Rats in the IR group were ischemic within 1 hour of clamping the left hepatic artery and left portal vein. Reperfusion for 2 hours was then done. IPC group, intermittent 2, 3, 5, and 7 minutes of reperfusion followed by 1 hour of warm ischemia. Two-minute reocclusion was done after each reperfusion. Rat sera were analyzed for AST and ALT, and Western blot analysis of rat liver tissue of rats evaluated malondialdehyde (MDA) and survivin.
Results: MDA in the liver tissue of rats in the IR and IPC group were significantly high than in the liver tissue of the SHAM group (P = 0.003 and P = 0.008, respectively). Survivin was higher in the IPC group than in the SHAM and IR groups (P = 0.021 and P = 0.024, respectively).
Conclusion: IPC could not prevent lipid oxidation in liver cell mitochondria, but did aid in the regeneration of ischemic injured liver cells. The results indicate that IPC can suppress the apoptosis of liver cells and reduce reperfusion injury of liver tissue.
목차
INTRODUCTION
METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (22)
참고문헌 신청
1. [학술지(정기간행물)] - Gross GJ. / 2007 / Reperfusion injury : does it exist? / J Mol Cell Cardiol 42 : 12 ~ 18
2. [학술지(정기간행물)] - Nauta RJ. / 1990 / Oxygen-derived free radicals in hepatic ischemia and reperfusion injury in the rat / Surg Gynecol Obstet 171 : 120 ~ 125
3. [학술지(정기간행물)] - Ryter SW. / 2007 / Mechanisms of cell death in oxidative stress / Antioxid Redox Signal 9 : 49 ~ 89
4. [학술지(정기간행물)] - Duffy MJ. / 2007 / Survivin : a promising tumor biomarker / Cancer Lett 249 : 49 ~ 60
5. [학술지(정기간행물)] - Ouhtit A. / 2007 / Survivin is not only a death encounter but also a survival protein for invading tumor cells / Front Biosci 12 : 1260 ~ 1270
2. [학술지(정기간행물)] - Nauta RJ. / 1990 / Oxygen-derived free radicals in hepatic ischemia and reperfusion injury in the rat / Surg Gynecol Obstet 171 : 120 ~ 125
3. [학술지(정기간행물)] - Ryter SW. / 2007 / Mechanisms of cell death in oxidative stress / Antioxid Redox Signal 9 : 49 ~ 89
4. [학술지(정기간행물)] - Duffy MJ. / 2007 / Survivin : a promising tumor biomarker / Cancer Lett 249 : 49 ~ 60
5. [학술지(정기간행물)] - Ouhtit A. / 2007 / Survivin is not only a death encounter but also a survival protein for invading tumor cells / Front Biosci 12 : 1260 ~ 1270
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UCI(KEPA) : I410-ECN-0101-2016-514-001396163