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자료유형
학술저널
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대한바이러스학회 JOURNAL OF BACTERIOLOGY AND VIROLOGY 大韓바이러스學會誌 제20권 제2호
발행연도
1990.12
수록면
177 - 181 (5page)

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This study was undertaken to define the sensitivity and specificity of the high density composite condensation particle agglutination (HDPA) method for serological diagnosis of HFRS and to evaluate the applicability of HDPA method for the measurement of antibody titers in sera from patients with HFRS. With sera from laboratory-proven patients with HFRS, experiments were carried out to compare, 1) the sensitivities of HDPA with that of indirect imrnunofluorescent antibody technique and 2)antibody titers measured by both methods, and to follow the increment of antibody titers with paired sera of patients with HFRS. The results were summarized as follows: 1. Statistically significant agreement was observed between results of serological diagnosis of HFRS by HDPA method and indirect immunofluorescent antibody technique. 2. Highly significant correlation was observed between antibody titers measured with indirect immunofluorescent antibody technique and HDPA method. (r=0.7614, p<0.001) 3. Of 10 paired sera of patients with active HFRS, four-fold or more increment of antibody titers appeared in 9 sera by test with HDPA method. This study indicated that the HDPA method is potential for the serologic diagnosis of HFRS.

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