지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2005.9
- 수록면
- 150 - 156 (7page)
이용수
초록· 키워드
오류제보하기
Dendritic cells (DCs) playa critical role not only in the initiation of immune responses, but also in the induction of immune tolerance. In an effort to regulate immune responses through the modulation of antigen presenting cell (APC) function of DCs, we searched for and characterized APC function modulators from natural products. Methods: DCs were cultured in the presence of propolis components, WP and CP, and then examined for their ability to present exogenous antigen in association with major histocompatibility complexes (MHC). Results: WP and CP inhibited class I MHC-restricted presentation of exogenous antigen (cross-presentation) in a DC cell line, DC2.4 cells, and DCs generated from bone marrow cells with GM-CSF and IL-4. The inhibitory activity of WP and CP appeared to be due not only to inhibition of phagocytic activity of DCs, but also to suppression of expression of MHC molecules on DCs. We also examined the effects of WP and CP on T cells. Interestingly, WP and CP increased IL-2 production from T cells. Conclusion: These results demonstrate that WP and CP inhibit MHC-restricted presentation of exogenous antigen through down-regulation of phagocytic activity and suppression of expression of MHC molecules on DCs.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Auranofin, an Immunosuppressive Drug, Inhibits MHC Class I and MHC Class II Pathways of Antigen Presentation in Dendritic Cells
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
2008 .01
-
Metformin Suppresses MHC-Restricted Antigen Presentation by Inhibiting Co-Stimulatory Factors and MHC Molecules in APCs
Biomolecules & Therapeutics(구 응용약물학회지)
2013 .01
-
Tacrolimus and cyclosporine A inhibit both class I-restricted presentation pathway and class II- restricted presentation pathway of exogenous antigen.
대한약학회 학술대회
2002 .01
-
Enhancement of Antigen Presentation Capability of Dendritic Cells and Activation of Macrophages by the Components of Bifidobacterium pseudocatenulatum SPM 1204
The journal of applied pharmacology : the official journal of the Korean Society of Applied Pharmacology
2005 .01
-
Linarin enhances both the presentation of exogenous particulate antigen in association of Class I Major Histocompatibility antigen and macrophage activation
대한약학회 학술대회
2003 .01
-
Lectins Isolated from Mushroom Fomitella fraxinea Enhance MHC-restricted Exogenous Antigen Presentation
Immune Network
2007 .12
-
Cordyceps militaris Enhances MHC-restricted Antigen Presentation via the Induced Expression of MHC Molecules and Production of Cytokines
Immune Network
2010 .08
-
Cyclooxygenase Inhibitors, Aspirin and Ibuprofen, Inhibit MHC-restricted Antigen Presentation in Dendritic Cells
Immune Network
2010 .06
-
Use of Cell-Penetrating Peptides in Dendritic Cell-Based Vaccination
Immune Network
2016 .02
-
Vitamin C Up-regulates Expression of CD80, CD86 and MHC Class II on Dendritic Cell Line, DC-1 Via the Activation of p38 MAPK
Immune Network
2012 .12
-
Korean Propolis enhances both the presentation of DC and macrophage activation
대한약학회 학술대회
2003 .01
-
Effects of Mizoribine on MHC-Restricted Exogenous Antigen Presentation in Dendritic Cells
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
2006 .01
-
Dendritic Cell as an effective cancer immuno-cell therapy module II. : Anti-tumor effect of cultured DCs in murine melanoma metastasis model
대한약학회 학술대회
2003 .01
-
수지상세포의 항원제시 능력 및 항암활성에 미치는 Lipofectin의 영향
Immune Network
2006 .06
-
Regulation of Intestinal Immune System by Dendritic Cells
Immune Network
2015 .02
-
Evidence for Direct Inhibition of MHC-Restricted Antigen Processing by Dexamethasone
Immune Network
2014 .12
-
Generation of Tolerogenic Dendritic Cells and Their Therapeutic Applications
Immune Network
2016 .02
-
T Cell"s Sense of Self : a Role of Self-Recognition in Shaping Functional Competence of Naïve T Cells
Immune Network
2017 .08
이 논문의 저자 정보
최근 본 자료
댓글(0)
0