지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.4
- 수록면
- 100 - 109 (10page)
이용수
초록· 키워드
오류제보하기
Controlling balance between T-helper type 1 (Th1) and T-helper type 2 (Th2) plays a pivotal role in maintaining the biological rhythm of Th1/Th2 and circumventing diseases caused by Th1/Th2 imbalance. Interleukin 4 (IL-4) is a Th2-type cytokine and often associated with hypersensitivity-related diseases such as atopic dermatitis and allergies when overexpressed. In this study, we have tried to elucidate the function of 1-palmitoyl-2-linoleoyl-3-acetyl-rac-glycerol (EC-18) as an essential modulator of Th1/Th2 balance. EC-18 has showed an inhibitory effect on the production of IL-4 in a dose-dependent manner. RT-PCR analysis has proved EC-18 affect the transcription of IL-4. By analyzing the phosphorylation status of Signal transducer and activator of transcription 6 (STAT6), which is a transcriptional activator of IL-4 expression, we discovered that EC-18 induced the decrease of STAT6 activity in several stimulated cell lines, which was also showed in STAT6 reporter analysis. Co-treatment of EC-18 significantly weakened atopy-like phenotypes in mice treated with an allergen. Collectively, our results suggest that EC-18 is a potent Th2 modulating factor by regulating the transcription of IL-4 via STAT6 modulation, and could be developed for immune-modulatory therapeutics.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (39)
참고문헌 신청
1. [학술지(정기간행물)] - Kleiman, R. / 1966 / Optically active aceto-triglycerides of oil from Euonymus verrucosus seed / Lipids 1 : 286 ~ 287
2. [학술지(정기간행물)] - Myher, J. J. / 1988 / Identification of the more complex triacylglycerols in bovine milk fat by gas chromatography-mass spectrometry using polar capillary columns / J. Chromatogr 452 : 93 ~ 118
3. [학술지(정기간행물)] - Limb, J. K. / 1999 / Isolation characterization of monoacetyldiglycerides from bovine udder / J. Lipid Res 40 : 2169 ~ 2176
4. [학술지(정기간행물)] - Yang, H. O. / 2004 / Purification structural determination of hematopoietic stem cell-stimulating monoacetyldiglycerides from Cervus nippon (deer antler) / Chem. Pharm. Bull 52 : 874 ~ 878
5. [기타자료] - Lee, T. S. / 2005 / Preparation of glycerol derivatives intermediates therefor. / KR 10-0789323
2. [학술지(정기간행물)] - Myher, J. J. / 1988 / Identification of the more complex triacylglycerols in bovine milk fat by gas chromatography-mass spectrometry using polar capillary columns / J. Chromatogr 452 : 93 ~ 118
3. [학술지(정기간행물)] - Limb, J. K. / 1999 / Isolation characterization of monoacetyldiglycerides from bovine udder / J. Lipid Res 40 : 2169 ~ 2176
4. [학술지(정기간행물)] - Yang, H. O. / 2004 / Purification structural determination of hematopoietic stem cell-stimulating monoacetyldiglycerides from Cervus nippon (deer antler) / Chem. Pharm. Bull 52 : 874 ~ 878
5. [기타자료] - Lee, T. S. / 2005 / Preparation of glycerol derivatives intermediates therefor. / KR 10-0789323
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Induction of Unique STAT Heterodimers by IL-21 Provokes IL-1RI Expression on CD8+ T Cells, Resulting in Enhanced IL-1β Dependent Effector Function
Immune Network
2021 .10
-
Interleukin-18 Receptor α Modulates the T Cell Response in Food Allergy
Allergy, Asthma & Immunology Research
2022 .07
-
T Cell-Specific Knockout of STAT3 Ameliorates Dextran Sulfate Sodium-Induced Colitis by Reducing the Inflammatory Response
Immune Network
2018 .08
-
STAT6 and PARP Family Members in the Development of T Cell-dependent Allergic Inflammation
Immune Network
2016 .08
-
IL-1 Receptor Dynamics in Immune Cells: Orchestrating Immune Precision and Balance
Immune Network
2024 .06
-
IL-4-induced forkhead box protein O regulates γc expression in T cells
한국실험동물학회 학술발표대회 논문집
2022 .07
-
Peroxiredoxin V specifically controls IL-6 production by regulating the Jak2-Stat5 pathway
한국실험동물학회 학술발표대회 논문집
2015 .08
-
Enhanced Antioxidant and Anticancer Properties of Processed Eucommiae Cortex
Natural Product Sciences
2019 .06
-
Gallic Acid Inhibits STAT3 Phosphorylation and Alleviates DDS-induced Colitis via Regulating Cytokine Production
동의생리병리학회지
2016 .01
-
Gallic Acid I nhibits STAT3 Phosphorylation and Alleviates DDS-induced Colitis via Regulating Cytokine Production
동의생리병리학회지
2016 .10
-
E-cigarette-associated Severe Pneumonia in Korea Using Data Linkage between the Korea National Health and Nutrition Examination Survey (KNHANES, 2013?2019) and the National Health Insurance Service (NHIS) Claims Database
Journal of Korean Medical Science
2021 .12
-
Ethics Committees: Structure, Roles, and Issues
Journal of Korean Medical Science
2023 .06
-
Comparative study on the EC50 values in single and mixtures of chemicals
한국실험동물학회 학술발표대회 논문집
2018 .07
-
IL6ST regulates liver tumorigenesis via the regulation of mitophagy
한국실험동물학회 학술발표대회 논문집
2021 .07
-
I-Kappa-B-Zeta Regulates Interleukin-17A/Tumor Necrosis Factor-Alpha Mediated Synergistic Induction of Interleukin-19 and Interleukin-20 in Humane Keratinocytes
Annals of Dermatology
2021 .01
-
Enhanced Type 2 Immune Reactions by Increased IL-22/IL-22Ra1 Signaling in Chronic Rhinosinusitis With Nasal Polyps
Allergy, Asthma & Immunology Research
2020 .01
-
The role of local IL6/JAK2/STAT3 signaling in high glucoseeinduced podocyte hypertrophy
Kidney Research and Clinical Practice
2016 .01
-
Current landscape and future perspective of sentinel node mapping in endometrial cancer
Journal of Gynecologic Oncology
2018 .01
-
IL-24 Contributes to Neutrophilic Asthma in an IL-17A-Dependent Manner and Is Suppressed by IL-37
Allergy, Asthma & Immunology Research
2022 .09
-
Patterns of Esophageal Cancer in the National Cancer Institute at the University of Gezira, in Gezira State, Sudan, in 1999-2012
Asian Pacific journal of cancer prevention : APJCP
2015 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-ECN-0101-2016-511-001746346