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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.9
- 수록면
- 197 - 206 (10page)
- DOI
- 10.14815/kjdm.2015.42.3.197
이용수
초록· 키워드
오류제보하기
Epigallocatechin gallate (EGCG), a flavonoid which is found in green tea and red wine, is known to have an osteogenic activity. In this study, the effect of EGCG on the differentiation of human dental pulp cells (HDPCs) was investigated. The growth of HDPCs was suppressed when the cells were exposed to 60 μM EGCG during 5 days. EGCG enhanced ALP activity of HDPCs at concentrations ranging from 10 to 30 μM. Furthermore, the mRNA expression of osteocalcin (OCN) and dentin sialophosphoprotein (DSPP) in HDPCs
was enhanced by exposure to EGCG. Extracellular matrix mineralization was also promoted by EGCG even in the absence of other odontogenic factors such as ascorbic acid and dexamethasone. Therefore, it is certain that EGCG is capable of inducing odontogenicity of dental pulp cells. In the experiment of biomimetic apatite coating of titanium discs, EGCG was successfully incorporated into apatite coats and released from the surfaces into culture media.
was enhanced by exposure to EGCG. Extracellular matrix mineralization was also promoted by EGCG even in the absence of other odontogenic factors such as ascorbic acid and dexamethasone. Therefore, it is certain that EGCG is capable of inducing odontogenicity of dental pulp cells. In the experiment of biomimetic apatite coating of titanium discs, EGCG was successfully incorporated into apatite coats and released from the surfaces into culture media.
목차
〈Abstract〉
Ⅰ. INTRODUCTION
Ⅱ. MATERIALS AND METHODS
Ⅲ. RESULTS
Ⅳ. DISCUSSION
Ⅴ. CONCLUSIONS
REFERENCES
참고문헌 (29)
참고문헌 신청
[학술지(정기간행물)] - Albuquerque MTP / 2014 / Tissue-engineering-based strategies for regenerative endodontics / J Dent Res 93 : 1222 ~ 1231
[학술지(정기간행물)] - Bègue-Kirn C / 1992 / Effects of dentin proteins, transforming growth factor β1 (TGF β1) and bone morphogenetic protein 2 (BMP2) on the differentiation of odontoblast in vitro / Int J Dev Biol 36 : 491 ~ 503
[학술지(정기간행물)] - Bessho K / 1991 / Human dentin-matrix-derived bone morphogenetic protein / J Dent Res 70 : 171 ~ 175
[학술지(정기간행물)] - Bradford M / 1976 / A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding / Anal Biochem 72 : 248 ~ 254
[학술지(정기간행물)] - Carturla N / 2003 / The relationship between the antioxidant and the antibacterial properties of galloylated catechins and the structure of phospholipid model membranes / Free Rad Biol Med 34 : 648 ~ 662
[학술지(정기간행물)] - Bègue-Kirn C / 1992 / Effects of dentin proteins, transforming growth factor β1 (TGF β1) and bone morphogenetic protein 2 (BMP2) on the differentiation of odontoblast in vitro / Int J Dev Biol 36 : 491 ~ 503
[학술지(정기간행물)] - Bessho K / 1991 / Human dentin-matrix-derived bone morphogenetic protein / J Dent Res 70 : 171 ~ 175
[학술지(정기간행물)] - Bradford M / 1976 / A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding / Anal Biochem 72 : 248 ~ 254
[학술지(정기간행물)] - Carturla N / 2003 / The relationship between the antioxidant and the antibacterial properties of galloylated catechins and the structure of phospholipid model membranes / Free Rad Biol Med 34 : 648 ~ 662
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UCI(KEPA) : I410-ECN-0101-2016-515-001905436