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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.12
- 수록면
- 59 - 66 (8page)
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Purpose: The aim of this study was to investigate the prognostic factor for elevating serum carcinoembryonic antigen (CEA) in patients with colorectal cancer and to identify clinical usefulness of tissue CEA.
Methods: Two hundred and eighty-five patients with colorectal cancer were performed serum CEA tests before and after surgery. Also resected tumors were checked expressions pattern of tissue CEA. Clinicopathologic factors were classified according to patient factors, tumor factors and molecular factors. Patient factors included age, sex, underlying liver disease, smoking history and other cancer history. Tumor factors included tumor size, intestinal obstruction, pathologic T status, lymph node metastasis, tumor differentiation, lymphatic invasion, vascular invasion, perineural invasion.
Results: Serum CEA level was markedly elevated in the cytoplasmic pattern of tissue CEA compared to membranous pattern of tissue CEA. As cancer stage progressed, serum CEA level was elevated, which was confined to cytoplasmic pattern of tissue CEA. Independent factors for the elevation of serum CEA by multivariate analysis included tumor size (≥5 cm) (P=0.042), complete intestinal Obstruction (P=0.023) and serum CA 19-9 (≥37 U/mL) (P=0.027). p53 overexpression (≥10%) was related to cytoplasmic pattern in tissue CEA (P=0.005).
Conclusion: The tumor size and bowel obstruction are considered the main factors, which cause the leakage of intracellular CEA. And membranous patterns of tissue CEA can be used in Stage I colorectal cancer patients, as an indicator for early prognosis and recurrence. However, more studies of colorectal population are required for further evaluation.
Methods: Two hundred and eighty-five patients with colorectal cancer were performed serum CEA tests before and after surgery. Also resected tumors were checked expressions pattern of tissue CEA. Clinicopathologic factors were classified according to patient factors, tumor factors and molecular factors. Patient factors included age, sex, underlying liver disease, smoking history and other cancer history. Tumor factors included tumor size, intestinal obstruction, pathologic T status, lymph node metastasis, tumor differentiation, lymphatic invasion, vascular invasion, perineural invasion.
Results: Serum CEA level was markedly elevated in the cytoplasmic pattern of tissue CEA compared to membranous pattern of tissue CEA. As cancer stage progressed, serum CEA level was elevated, which was confined to cytoplasmic pattern of tissue CEA. Independent factors for the elevation of serum CEA by multivariate analysis included tumor size (≥5 cm) (P=0.042), complete intestinal Obstruction (P=0.023) and serum CA 19-9 (≥37 U/mL) (P=0.027). p53 overexpression (≥10%) was related to cytoplasmic pattern in tissue CEA (P=0.005).
Conclusion: The tumor size and bowel obstruction are considered the main factors, which cause the leakage of intracellular CEA. And membranous patterns of tissue CEA can be used in Stage I colorectal cancer patients, as an indicator for early prognosis and recurrence. However, more studies of colorectal population are required for further evaluation.
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UCI(KEPA) : I410-ECN-0101-2016-513-002430256